| UC | ulcerative colitis; ultracentrifugal; umbilical cord; unchanged; unclassifiable; unconscious; undiff... |
|---|---|
| HSC | Hand-Schuller-Christian [syndrome]; Health and Safety Commission; health sciences center; health scr... |
| LMS | lateral medullary syndrome; left main stem [coronary artery]; leiomyosarcoma; Licentiate in Medicine... |
| ABC | absolute basophil count; absolute bone conduction; acalculous biliary colic; acid balance control; a... |
| ASCT | autologous stem cell transplantation |
D factor
| multiple cloning site | Region of a phage or plasmid vector that has been engineered to contain a series of restriction sites that are usually unique within the entire vector. This makes it particularly easy to insert or excise (subclone) DNA fragments. (18 Nov 1997) |
|---|---|
| positional cloning | Cloning a gene based simply on knowing its position in the genome without any idea of the function of that gene. Because this is the reverse of how things have been traditionally done, it has also been called reverse genetics. (12 Dec 1998) |
| self cloning | <molecular biology> Any system in which inappropriate cell types or organisms are eliminated because they possess some character that allows them to die or to remove themselves from the system. Thus a transfected cell with genetic material including a drug resistance marker will be self cloning in the presence of the drug and nontransfected cells will die. (18 Nov 1997) |
| dilution cloning | Cloning by diluting the cell suspension to the point at which the probability of there being more than one cell in the inoculum volume is small. Inevitably on quite a few occasions there will not be any cells. (18 Nov 1997) |
| directional cloning | DNA insert and vector molecules are digested with two different restriction enzymes to create noncomplementary sticky ends at either endof each restriction fragment. This allows the insert to be ligated tothe vector in a specific orientation and prevents the vector fromrecircularising. (09 Oct 1997) |
| DNA cloning | The use of DNA manipulation procedures to produce multiple copies of a single gene or segment of DNA. (12 Dec 1998) |
| expression cloning | <molecular biology> A vector that results in the expression of inserted DNA sequences when propagated in a suitable host cell, i.e. The protein coded for by the DNA is synthesised by the host's system. (06 Aug 1998) |
| peripheral blood stem cell transplantation | A procedure that is similar to bone marrow transplantation. Doctors remove healthy immature cells (stem cells) from a patient's blood and store them before the patient receives high-dose chemotherapy and possibly radiation therapy to destroy the leukaemia cells. The stem cells are then returned to the patient, where they can produce new blood cells to replace cells destroyed by the treatment. (12 Dec 1998) |
| pipe stem cirrhosis | Cirrhosis of the liver with finger-like fibrosis predominantly around portal tracts, seen in schistosomiasis. Leads to portal hypertension but rarely to functional failure of the liver. (05 Mar 2000) |
| pluripotent stem cell | <haematology> Cells in a stem cell line capable of differentiating into several different final differentiated types, for example there may be a pluripotent stem cell line for erythrocytes, granulocytes and megakaryocytes. (11 Mar 1998) |
| haematopoietic stem cell mobilization | The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantion. Haematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization. (12 Dec 1998) |
| haematopoietic stem cell transplantation | The transference of stem cells from one animal or human to another (allogeneic), or within the same individual (autologous). The source for the stem cells may be the bone marrow or peripheral blood. Stem cell transplantation has been used as an alternative to autologous bone marrow transplantation in the treatment of a variety of neoplasms. (12 Dec 1998) |
| haemopoietic stem cell | <haematology> Cell that gives rise to distinct daughter cells, one a replica of the stem cell, one a cell that will further proliferate and differentiate into a mature blood cell. Pluripotent stem cells can give rise to all lineages, committed stem cells (derived from the pluripotent stem cell) only to some. (18 Nov 1997) |
| hematopoietic stem cell | <haematology> Cell that gives rise to distinct daughter cells, one a replica of the stem cell, one a cell that will further proliferate and differentiate into a mature blood cell. Pluripotent stem cells can give rise to all lineages, committed stem cells (derived from the pluripotent stem cell) only to some. (18 Nov 1997) |
| stem | The main stem or a branch of the main axial system of a plant, developed from the plumule of the embryo and typically bearing leaves. (09 Oct 1997) |