| central areolar choroidal sclerosis | A slowly progressive pigmentary degeneration in young persons; characterised by black foci closely set together and coalescent at the posterior pole and macular region. Synonym: central areolar choroidal atrophy, central areolar choroidal sclerosis. (05 Mar 2000) |
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| cerebral sclerosis, diffuse | Diffuse progressive degeneration of the white matter of the brain, accompanied by mental deterioration, severe motor disturbances, and early death. (12 Dec 1998) |
| menstrual sclerosis | A slowly progressive sclerosis in the walls of the ovarian arteries which commences after puberty. Synonym: menstrual sclerosis, ovulational sclerosis. (05 Mar 2000) |
| physiologic sclerosis | A slowly progressive sclerosis in the walls of the ovarian arteries which commences after puberty. Synonym: menstrual sclerosis, ovulational sclerosis. (05 Mar 2000) |
| Monckeberg's sclerosis | Arterial sclerosis involving the peripheral arteries, especially of the legs of older people, with deposition of calcium in the medial coat (pipestem arteries) but with little or no encroachment on the lumen. Synonym: medial arteriosclerosis, Monckeberg's calcification, Monckeberg's degeneration, Monckeberg's medial calcification, Monckeberg's sclerosis. (05 Mar 2000) |
| combined sclerosis | A subacute or chronic disorder of the spinal cord, such as that occurring in certain patients with vitamin B12 deficiency, characterised by a slight to moderate degree of gliosis in association with spongiform degeneration of the posterior and lateral columns. Synonym: combined sclerosis, combined system disease, funicular myelitis, Putnam-Dana syndrome, vitamin B12 neuropathy. (05 Mar 2000) |
| multiple sclerosis | <neurology> Neurodegenerative disease characterised by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in 3rd or 4th decade with intermittent progression over an extended period. Cause still uncertain. (18 Nov 1997) |
| posterior sclerosis | See Tabes dorsalis. (12 Dec 1998) |
| posterior spinal sclerosis | See Tabes dorsalis. (12 Dec 1998) |
| primary lateral sclerosis | Considered by many to be a subgroup of motor neuron disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral cortex, resulting in widespread weakness on an upper motor neuron basis; spasticity, hyperreflexia, and Babinski signs are present, but not fasciculation potentials, nor any electrodiagnostic evidence of a lower motor neuron lesion. Synonym: lateral spinal sclerosis. (05 Mar 2000) |
| sclerosis | <pathology> A induration or hardening, especially hardening of a part from inflammation and in diseases of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or to designate hardening of the blood vessels. Origin: Gr. Sklerosis = hardness (18 Nov 1997) |
| sclerosis corii | <dermatology> Hardening of skin. (04 Mar 1998) |
| sclerosis cutanea | Synonym: scleroderma. (05 Mar 2000) |
| sclerosis, multiple | The National Multiple Sclerosis Society says of ms that it is a disease that randomly attacks your central nervous system, wearing away the control you have over your body. Symptoms may range from numbness to paralysis and blindness. The progress, severity and specific symptoms cannot be foreseen. You never know when attacks will occur, how long they will last, or how severe they will be. most people are diagnosed with ms between the ages of 20 and 40. In medical terms, ms involves demyelinization of the white matter sometimes extending into the gray matter. Demyelinization is loss of myelin, the coating of nerve fibres composed of lipids (fats) and protein that serves as insulation and permits efficient nerve fibre conduction. The white matter is the part of the brain which contains myelinated nerve fibres and appears white, whereas the gray matter is the cortex of the brain which contains nerve cell bodies and appears gray. When myelin is damaged in ms, nerve fibre conduction is faulty or absent. Impaired bodily functions or altered sensations associated with those demyelinated nerve fibres give rise to the symptoms of ms. Recent research (1998) has also identified nerve cell death as part of the nervous system injury in ms. (12 Dec 1998) |
| sclerosis of white matter | <radiology> Type of dysmyelinating disease, hereditary, peripheral nervous system unaffected in some disorders Specific diseases: adrenoleukodystrophy, metachromatic leukodystrophy, spongy degeneration (Canavan), globoid cell (Krabbe) leukodystrophy, Alexander disease, Pelizaeus-Merzbacher disease, Cockayne syndrome (12 Dec 1998) |