| cholesterol monooxygenase | <enzyme> Multi-enzyme complex required for the conversion of cholesterol to adrenal cortex hormones. It releases methylpentanoate or isocaproaldehyde and pregnenolone. The complex contains cytochrome p-450, a flavoprotein, a non-haem iron protein, and NADPH. Chemical name: Cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving) Registry number: EC 1.14.15.6 (12 Dec 1998) |
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| methane monooxygenase | <enzyme> Mmoc encodes protein c of soluble methane monooxygenase (smmo); pmmo (membrane-associated methane monooxygenase) contains 4 moles of nonheme iron and 1 mole of copper per mole enzyme complex Registry number: EC 1.14.13.25 Synonym: methane monooxygenase component a, methane monooxygenase component c, methane monooxygenase hydroxylase, mmoc gene product, pmmo gene product (26 Jun 1999) |
| methanesulfonic acid monooxygenase | <enzyme> Catalyses conversion of methanesulfonic acid to formaldehyde and sulfite; requires NADH; consists of a, b, and c components; component c is an iron-sulfur protein Registry number: EC 1.14.13.- Synonym: msa monooxygenase, msmc component (26 Jun 1999) |
| choline monooxygenase | <enzyme> Catalyses conversion of choline to the hydrate form of betaine aldehyde. Registry number: EC 1.- Synonym: cmo enzyme (26 Jun 1999) |
| phenylalanine 4-monooxygenase | <enzyme> An enzyme that catalyses the oxidation of l-phenylalanine to l-tyrosine with O2 and tetrahydrobiopterin (the latter forming the dihydro derivative) which is reduced by NADPH and a reductase to the active form; a deficiency of either of these enzymes will result in phenylketonuria. Synonym: phenylalanine 4-hydroxylase. (05 Mar 2000) |
| monophenol monooxygenase | <enzyme> An enzyme of the oxidoreductase class that catalyses the reaction between l-tyrosine, l-dopa, and oxygen to yield l-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as catechol oxidase. Chemical name: Monophenol,L-dopa:oxygen oxidoreductase Registry number: EC 1.14.18.1 (12 Dec 1998) |
| cyclopentanone monooxygenase | <enzyme> From pseudomonas ncimb 9872; catalyses the conversion of cyclopentanone to 5-valerolactone in the presence of NADPH and oxygen Registry number: EC 1.14.13.16 Synonym: cyclopentanone 1,2-monooxygenase (26 Jun 1999) |
| prostaglandin E1 monooxygenase | <enzyme> Requires NADPH; liver microsome enzyme is cytochrome p-450 dependent; catalyses omega hydroxylation Registry number: EC 1.14.- Synonym: pge1 monooxygenase (26 Jun 1999) |
| xylene monooxygenase | <enzyme> Coded by the tol plasmid of pseudomonas putida, oxidises the methyl side chain of toluene and xylenes Registry number: EC 1.14.13.- (26 Jun 1999) |
| secondary amine monooxygenase | <enzyme> Catalyses NADH or NADPH dependent oxidative n-dealkylation of short chain aliphatic secondary amines with a methyl or ethyl group Registry number: EC 1.14.99.- Synonym: dimethylamine mono-oxygenase, secondary amine mono-oxygenase (26 Jun 1999) |
| pyrrole-2-carboxylate monooxygenase | <enzyme> Consists of 18.7- and 54-kD subunits; the 18.7-kD subunit is an NADH-oxidase; the 54-kD subunit requires NADH and fad; isolated from rhodococcus Registry number: EC 1.14.13.- Synonym: pyrrole-2-cooh monooxygenase (26 Jun 1999) |
| N-acetylneuraminate monooxygenase | <enzyme> Forms n-glycolylneuraminate; see also EC 1.14.13.15 which converts cmp-n-acetylneuraminate to cmp-n-glycolylneuraminate Registry number: EC 1.14.99.18 Synonym: n-acetylneuraminic acid hydroxylase, neuac hydroxylase (26 Jun 1999) |
| steroid 11 beta-monooxygenase | <enzyme> A steroid hydroxylase system found in adrenal tissues. It catalyses the 11-hydroxylation of steroids in the presence of molecular oxygen and consists of an NADPH-specific flavoprotein, a non-haem iron protein, and cytochrome p-450. Its deficiency is a cause of congenital adrenal hyperplasia (adrenal hyperplasia, congenital). Chemical name: Steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating) Registry number: EC 1.14.15.4 (12 Dec 1998) |
| steroid 12-monooxygenase | <enzyme> A steroid hydroxylase found in liver microsomes. It catalyses the 12-hydroxylation of steroids in the presence of NADPH, cytochrome p-450, and molecular oxygen. It is an important enzyme in the synthesis of cholic acid from cholesterol in the liver. Chemical name: Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating) Registry number: EC 1.14.99.- (12 Dec 1998) |
| steroid 17 alpha-monooxygenase | <enzyme> A steroid hydroxylase system found in the microsomal membrane of the steroid-hormone producing tissues. It catalyses the 17-hydroxylation of steroids, such as progesterone or pregnenolone in the presence of NADPH and molecular oxygen. This is an important step in the biosynthesis of steroid hormones. Chemical name: Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating) Registry number: EC 1.14.99.9 (12 Dec 1998) |