| direct reacting bilirubin | The fraction of serum bilirubin which has been conjugated with glucuronic acid in the liver cell to form bilirubin diglucuronide; so called because it reacts directly with the Ehrlich diazo reagent; increased levels are found in hepatobiliary diseases, especially of the obstructive variety. Synonym: conjugated bilirubin. (05 Mar 2000) |
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| indirect bilirubin | <biochemistry> Free bilirubin that has not been attached to a glucuronide molecule. This results from the rapid breakdown of red blood cells. The haemoglobin molecule is normally converted to bilirubin. Greater than normal values of indirect bilirubin can be seen in erythroblastosis foetalis, haemolytic anaemia, sickle cell anaemia, transfusion reactions, pernicious anaemia and resolution of large haematomas. (27 Sep 1997) |
| indirect reacting bilirubin | The fraction of serum bilirubin which has not been conjugated with glucuronic acid in the liver cell; so called because it reacts with the Ehrlich diazo reagent only when alcohol is added; increased levels are found in hepatic disease and haemolytic conditions. Synonym: unconjugated bilirubin. (05 Mar 2000) |
| UDPglucuronate-bilirubin glucuronosyltransferase | Hepatic transferases that catalyze the transfer of the glucuronic moiety of UDP-glucuronic acid to bilirubin or bilirubin glucuronide, thus producing UDP and either bilirubin-glucoronoside or bilirubin bisglucuronoside, respectively; these bile conjugates are then secreted into the bile. Synonym: UDPglucuronate-bilirubinglucuronoside glucuronosyltransferase. (05 Mar 2000) |
| unconjugated bilirubin | <biochemistry> Free bilirubin that has not been attached to a glucuronide molecule. This results from the rapid breakdown of red blood cells. The haemoglobin molecule is normally converted to bilirubin. Greater than normal values of indirect bilirubin can be seen in erythroblastosis foetalis, haemolytic anaemia, sickle cell anaemia, transfusion reactions, pernicious anaemia and resolution of large haematomas. (27 Sep 1997) |