| cellular immunodeficiency with abnormal immunoglobulin synthesis | An ill-defined group of sporadic disorders of unknown cause, occurring in both males and females and associated with recurrent bacterial, fungal, protozoal, and viral infections; there is thymic hypoplasia with depressed cellular (T-lymphocyte) immunity combined with defective humoral (B-lymphocyte) immunity, although immunoglobulin levels may be normal. Synonym: Nezelof syndrome, Nezelof type of thymic alymphoplasia. (05 Mar 2000) |
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| haemoglobins, abnormal | Haemoglobins altered in their genetically determined molecular structure, resulting in a characteristic complex of vlinival and laboratory abnormalities. The specific features of the abnormal haemoglobins are related to variation of the composite globin polypeptide chains. (12 Dec 1998) |
| pupillary functions, abnormal | Conditions in which the pupil does not react normally to dilation and constriction. Signs of pupillary abnormalities originate from the pupil's shape, position, and response to stimulation. (12 Dec 1998) |
| fibrinogens, abnormal | Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilised fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenaemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing. (12 Dec 1998) |
| Benedict's test for glucose | <biochemistry> A copper-reduction test for glucose in the urine, which involves thiocyanate in addition to copper sulfate for qualitative or quantitative use. (14 Aug 2000) |
| glucose oxidase paper strip test | <chemical pathology> A qualitative test for glucose in the urine, in which glucose is oxidised to gluconic acid by glucose oxidase; a specific test, unless ascorbic acid is present. (05 Mar 2000) |
| acoustic tolerance | The maximum sound pressure level that can be experienced without producing pain or permanent defect of hearing in a normal individual. (05 Mar 2000) |
| radiation tolerance | The ability of some cells or tissues to withstand ionizing radiation without serious injury. Tolerance depends on the species, cell type, and physical and chemical variables, including radiation-protective agents and radiation-sensitizing agents. (12 Dec 1998) |
| pain tolerance | The greatest intensity of painful stimulation that an individual is able to tolerate. (05 Mar 2000) |
| gamma-tolerance | The tolerance of a person or a piece of equipment to forces that develop as a result of acceleration or deceleration. (05 Mar 2000) |
| vibration tolerance | The maximum vibratory or oscillatory movements that an individual can experience and bear without pain; the limit of tolerance is a function of amplitude and frequency of the vibration and varies with the direction of application. (05 Mar 2000) |
| work schedule tolerance | Physiological or psychological effects of periods of work which may be fixed or flexible such as flexitime, work shifts, and rotating shifts. (12 Dec 1998) |
| cross tolerance | <pharmacology> The resistance to one or several effects of a compound as a result of tolerance developed to a pharmacologically similar compound. (05 Mar 2000) |
| high dose tolerance | The induction of tolerance by exposure to high doses of antigen. (05 Mar 2000) |
| self tolerance | The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognise the difference between self and non-self is the prime function of the immune system. (12 Dec 1998) |