| blocked reading frame | A sequence of DNA that cannot be translated into a viable protein; usually due to the interruption by one or more termination codons. Synonym: closed reading frame. (05 Mar 2000) |
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| reading frame | One of the three possible ways of reading a nucleotide sequence. As the genetic code is read in nonoverlapping triplets (codons) there are three possible ways of translating a sequence of nucleotides into a protein, each with a different starting point. For example: given the nucleotide sequence: AGCAGCAGC, the three reading frames are: AGC AGC AGC, GCA GCA, CAG CAG. (18 Nov 1997) |
| reading frame, open | An open reading frame in DNA has no termination codon, no signal to stop reading the nucleotide sequence, and so may be translated into protein. (12 Dec 1998) |
| reading frames | The sequence of codons by which translation may occur. A segment of mRNA 5'auccga3' could be translated in three reading frames, 5'auc.. Or 5'ucc.. Or 5'ccg.., depending on the location of the start codon. (12 Dec 1998) |
| reading-frameshift mutation | <molecular biology> A type of mutation that results from insertion or deletion of a single nucleotide into, or from, an open reading frame in the normal DNA sequence. Normally, the genetic code is read in the wrong frame, three nucleotides at a time, and the entire sequence downstream of the mutation, is translated into a polypeptide with a garbled amino acid sequence from the mutated codon onwards. These mutations may be induced by certain types of mutagens or may occur spontaneously and usually result in the generation, downstream, of nonsense, chain termination codons. Synonym: addition mutation, addition-deletion mutation, deletion mutation, reading-frameshift mutation. (21 Jun 2000) |
| mind-reading | The knowledge or communication by one person with the mental processes of another through channels other than known physical or perceptual processes. (12 Dec 1998) |
| closed reading frame | A sequence of DNA that cannot be translated into a viable protein; usually due to the interruption by one or more termination codons. Synonym: closed reading frame. (05 Mar 2000) |
| open reading frame | <molecular biology> A reading frame in a sequence of nucleotides in DNA that contains no termination codons and so can potentially translate as a polypeptide chain. (18 Nov 1997) |
| open reading frames | Reading frames where successive nucleotide triplets can be read as codons specifying amino acids and where the sequence of these triplets is not interrupted by stop codons. (12 Dec 1998) |
| overlapping reading frame | <molecular biology> Start codons in different reading frames which generate different polypeptides from the same DNA sequence. (09 Oct 1997) |
| unidentified reading frame | <molecular biology> A reading frame in a sequence of nucleotides in DNA that contains no termination codons and so can potentially translate as a polypeptide chain. (18 Nov 1997) |
| antenatal diagnosis | Determination of the nature of a pathological condition or disease in the postimplantation embryo, foetus, or pregnant female before birth. (12 Dec 1998) |
| pathologic diagnosis | A diagnosis, sometimes postmortem, made from an anatomic and/or histologic study of the lesions present. (05 Mar 2000) |
| clinical diagnosis | A diagnosis made from a study of the signs and symptoms of a disease. (05 Mar 2000) |
| physical diagnosis | A diagnosis made by means of physical examination of the patient, or the process of a physical examination. (05 Mar 2000) |