| aspartate transaminase | <enzyme> An enzyme of the transferase class that catalyses the reaction of l-aspartate and 2-ketoglutarate to yield oxaloacetate and l-glutamate. The enzyme is a pyridoxal phosphate protein. In the liver the reaction transfers excess metabolic nitrogen into aspartate for disposal in the urea cycle. Chemical name: L-Aspartate:2-oxoglutarate aminotransaminase Registry number: EC 2.6.1.1 (12 Dec 1998) |
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| aspartate-trna ligase | <enzyme> An enzyme that activates aspartic acid with its specific transfer RNA. Chemical name: L-Aspartate:tRNA-(Asp) ligase (AMP-forming) Registry number: EC 6.1.1.12 (12 Dec 1998) |
| malate-aspartate shuttle | A mechanism for the transfer of NADH reducing equivalents from the cytosol into the mitochondria using two isozymes of malate dehydrogenase and aspartate transaminase. (05 Mar 2000) |
| receptors, n-methyl-d-aspartate | A class of ionotropic glutamate receptors characterised by affinity for n-methyl-d-aspartate. Nmda receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity. (12 Dec 1998) |
| potassium magnesium aspartate | <chemical> An intra-extracellular electrolyte exchange agent with a variety of effects. Beneficial in cardiac insufficiency, potentiates the effect of cardiac glycosides by reducing their toxicity, has hypocholesteraemic effects and potentiates the effects of calcium in disturbed calcium metabolism. Synonym: panangin; tromcardin. Chemical name: DL-Aspartic acid, monopotassium salt, mixt. With potassium hydrogen (T-4)-bis(DL-aspartato(2-)-N,O1)magnesate(2-) (12 Dec 1998) |
| protein-D-aspartate methyltransferase | <enzyme> For protein carboxymethylases consider also protein o-methyltransferase Registry number: EC 2.1.1.77 Synonym: d-aspartyl-l-isoaspartyl methyltransferase, protein d-aspartate-l-isoaspartate methyltransferase, protein l-isoaspartate o-methyltransferase, protein-beta-aspartate methyltransferase, protein-l-isoaspartate methyltransferase, protein l-isoaspartyl methyltransferase, isoaspartyl-aspartyl protein methyltransferase, protein-d-asp methyltransferase, l-isoaspartyl protein carboxymethyltransferase, pcm gene product, pcmt1 gene product (26 Jun 1999) |
| N-acyl-D-aspartate amidohydrolase | <enzyme> Specific for d-aspartate; amino acid sequence given in first source Registry number: EC 3.5.1.- Synonym: d-aaase, n-acyl-d-asp amidohydrolase (26 Jun 1999) |
| N methyl D aspartate receptor | <physiology> Glutamate receptor sub type (see excitatory amino acids). N methyl D aspartate receptor channels seem to be potentiated by intracellular arachidonic acid. Acronym: NMDA (26 Mar 1998) |
| IMP-aspartate ligase | <enzyme> A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyses the synthesis of adenylosuccinate from GTP, imp, and aspartate with the formation of orthophosphate and GDP. Chemical name: IMP:L-aspartate ligase (GDP-forming) Registry number: EC 6.3.4.4 (12 Dec 1998) |
| L-aspartate oxidase | <enzyme> E coli enzyme; forms unstable product, iminoaspartate; b protein of quinolinate synthetase Registry number: EC 1.4.3.16 Synonym: b-protein, quinolinate synthetase, l-aspartate - fumarate oxidoreductase (26 Jun 1999) |