| threonyl tRNA synthetase kinase | <enzyme> From postribosomal supernatants of bom:nmri mouse liver; comigrates with threonyl trna synthetase during several purification steps Registry number: EC 2.7.1.- Synonym: thr trna synthetase kinase (26 Jun 1999) |
|---|---|
| thymidine kinase | <enzyme> Of pyrimidine salvage, catalysing phosphorylation of thymine deoxyriboside to form its 5' phosphate, the nucleotide thymidylate. Animal cells lacking this enzyme can be selected by lethal synthesis, for example by resistance to bromodeoxyuridine and can be used as parentals in somatic hybridisation, since they are unable to grow in HAT medium. (18 Nov 1997) |
| ectoprotein kinase | <enzyme> From outer plasma membranes; active site and substrate oriented extracellularly Registry number: EC 2.7.1.- Synonym: ecto-protein kinase, ectokinase (26 Jun 1999) |
| TIE-2 receptor tyrosine kinase | <enzyme> Expressed in developing vascular endothelial cells; unlike tie-1, also expressed in lens epithelium and heart epicardium; has the same organization of amino acid sequence motifs characteristic of tie-1; aa sequence of the intracellular and extracellular regions of tie-1 and tie-2 are 79% and 32% identical, respectively; aa sequence of both kinases given in first source Registry number: EC 2.7.10.- Synonym: tie-2-rtk (26 Jun 1999) |
| tie receptor tyrosine kinase | <enzyme> From human leukaemia cells; expressed in developing vascular endothelial cell; has homology with egf, bfgf, csf-1, pdgf and stem cell factor receptors; ligand and biologic function not known as of 12/92; tie-1 receptor tyrosine kinase is rat homolog of tie receptor tyrosine kinase; aa sequence known Registry number: EC 2.7.10.- Synonym: tie-1 receptor tyrosine kinase, tie-1 rtk (26 Jun 1999) |
| eif-2 kinase | <enzyme> A dsrna-activated camp-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsrna and ATP, eif-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyses the phosphorylation of the alpha subunit of eif-2, leading to the inhibition of protein synthesis. Registry number: EC 2.7.10.- (12 Dec 1998) |
| tropomyosin kinase | <enzyme> From chick embryo; requires mg; ca and cyclic AMP not needed Registry number: EC 2.7.1.132 (26 Jun 1999) |
| TTK kinase | <enzyme> Can phosphorylate serine, threonine and tyrosine hydroxyamino acids and is associated with cell proliferation; amino acid sequence given in first source Registry number: EC 2.7.10.- (26 Jun 1999) |
| estradiol receptor tyrosine kinase | <enzyme> Calcium and calmodulin dependent Registry number: EC 2.7.1.- Synonym: ertk (26 Jun 1999) |
| tyrosine kinase | <enzyme> Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand binding domain, a single transmembrane domain and an intracellular tyrosine kinase domain and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (18 Nov 1997) |
| tyrosyl tRNA synthetase kinase | <enzyme> From postribosomal supernatants of bom:nmri mouse liver; comigrates with tyrosyl trna synthetase during several purification steps Registry number: EC 2.7.1.- Synonym: tyr trna synthetase kinase (26 Jun 1999) |
| kanamycin kinase | <enzyme> A class of enzymes that inactivate aminoglycoside-aminocyclitol antibiotics by regiospecific phosphorylation of the 3' and/or 5' hydroxyl. Chemical name: ATP:kanamycin 3'-O-phosphotransferase Registry number: EC 2.7.1.95 (12 Dec 1998) |
| Yrk kinase | <enzyme> Non-receptor type protein kinase of src family; consists of 536 amino acids and has all the canonical features of a src kinase; expressed at elevated levels in neuronal and haematopoietic tissues; amino acid sequence given in first source Registry number: EC 2.7.1.- Synonym: yes-related kinase, yrk protein (26 Jun 1999) |
| YRP kinase | <enzyme> Yrp - tyrosine-regulated protein kinase; activated by v-src and protein kinase c-mediated signal transduction pathways Registry number: EC 2.7.10.- (26 Jun 1999) |
| YSK1 kinase | <enzyme> Ysk1 - yeast sps1/ste20-related kinase 1; a mammalian kinase structurally related to ste20 and sps1 but not involved in known mapk pathways; amino acid sequence given in first source Registry number: EC 2.7.10.- (26 Jun 1999) |