| bone metastases | <radiology> Sensitivity . . . . . . . . . . . . . . . . . . . . . . . . . 98%, False negatives: multiple myeloma, thyroid carcinoma, small, purely lytic lesions, oat cell carcinoma Specificity . . . . . . . . . . . . . . . . . . . . . . . . High, False positives: Paget's disease, arthritis, fibrous dysplasia, infection, trauma, new or old REF: MacNeil BJ. Value of bone scanning in neoplastic disease. Semin Nucl Med 14:277, 1984. (12 Dec 1998) |
|---|---|
| bone metastases in kids | <radiology> Rhabdomyosarcoma, neuroblastoma, histiocytosis X Note: Wilms tumour goes to lung, not bone (12 Dec 1998) |
| bone morphogenetic protein | <protein> Activity derived from bone that induces the formation of cartilage and bone in vivo. Seven bone morphogenetic proteins have been described, BMP 1 being the only one not in the TGF beta superfamily. BMP 3 was formerly called osteogenin. Acronym: BMP (18 Nov 1997) |
| bone morphogenetic proteins | Non-collagenous factors, believed to be proteins, that occur in demineralised bone and stimulate osteogenesis. They can induce new bone formation in ectopic sites and thus have potential use in bone repair. (12 Dec 1998) |
| bone nails | Rods of bone, metal, or other material used for fixation of the fragments or ends of fractured bones. (12 Dec 1998) |
| bone phosphate | Ca3(PO4)2;used as an antacid. Synonym: bone ash, bone phosphate, tertiary calcium phosphate, tricalcium phosphate, whitlockite. (05 Mar 2000) |
| bone plate | A metal bar with perforations for the insertion of screws; used to immobilise fractured segments. (05 Mar 2000) |
| bone plates | Metal bars with perforations for the insertion of screws, used to immobilise fractured segments. (12 Dec 1998) |
| bone reflex | A reflex excited by a stimulus applied to a bone. (05 Mar 2000) |
| bone regeneration | Renewal or repair of lost bone tissue. It excludes callus formed after bone fracture but not yet replaced by hard bone. (12 Dec 1998) |
| bone remodeling | The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as osteoporosis. (12 Dec 1998) |
| bone resorption | Bone loss due to osteoclastic activity. (12 Dec 1998) |
| bone-salt | The main chemical compound in bone, deposited as minute amorphous crystals in a netlike matrix of collagenous fibres containing collagen; it closely resembles the naturally occurring fluorapatite 3Ca3(PO4)2-CaF2, but is probably a hydroxyapatite in which F is replaced by OH. (05 Mar 2000) |
| bone scan | <investigation, radiology> A study of the body skeleton. A dose of radioactive substance is injected and the scan (taken a little time later) reads the distribution of the radioactivity. (16 Dec 1997) |
| bone scan: falsely negative metastases | <radiology> Anaplastic tumours, reticulum cell sarcoma, renal cell carcinoma, thyroid carcinoma, histiocytosis, neuroblastoma, multiple myeloma (positive scan usually due to recent or impending fracture) (12 Dec 1998) |