| high-altitude pulmonary e. |
pulmonary edema caused by hypoxia from excessive physical exertion after ascending quickly to a high altitude without acclimatization. See also high-altitude sickness, under sickness.
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| high-altitude s. |
altitude s.
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| high-assimilation p. |
see assimilation p.
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| high-ceiling d.’s |
agents that inhibit the reabsorption of sodium and water in the thick ascending limb of the loop of Henle. They promote a high level of diuresis and their effect is not altered by acid-base imbalances or hypoalbuminemia. Used in the treatment of edema associated with congestive heart failure, acute pulmonary edema, or hepatic or renal disease and, alone or in combination with other drugs, in the treatment of hypertension.
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| high-density l. |
a class of lipoproteins frequently divided into HDL2 and HDL3 (see table) and the minor variant HDL1 (see Lp(a) l.). HDL promotes transport of cholesterol from extrahepatic tissue to the liver for excretion in the bile; synthesized by the liver as discoid “nascent HDL” particles lacking a lipid core, it accumulates a core of cholesteryl esters during reverse cholesterol transport (q.v.) and transfers them to the liver directly or indirectly via other lipoproteins. HDL also shuttles apolipoproteins C-II and E to and from triglyceride-rich lipoproteins during catabolism of the lipoproteins. Serum HDL cholesterol has been negatively correlated with premature coronary heart disease. Called also (referring to its electrophoretic mobility) α-l.
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