| interferon-beta | <cytokine> One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity. Synonym: fibroblast interferon. Pharmacological action: adjuvants, immunologic, antineoplastic agent, antiviral agents. Chemical name: Interferon-alphaB (human leukocyte protein moiety reduced) (12 Dec 1998) |
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| IV(3)beta-glucuronyl neolactotetraosylceramide sulfotransferase | <enzyme> Catalyses the final step in sulfoglucuronyl glycolipid biosynthesis, in which sulfate from 3'-phosphoadenosine 5'-phosphosulfate is transferred to a hydroxy group on carbon 3 of the terminal glucuronyl residue in iv(3)beta-glucuronyl neolactotetraosylceramide Registry number: EC 2.8.2.- Synonym: ggl-st, glcanlcose(4)cer sulfotransferase, glucuronylglycolipid sulfotransferase, ggl-3-sulfotransferase (26 Jun 1999) |
| testosterone 16 beta-hydroxylase | <enzyme> See also record for testosterone hydroxylase Registry number: EC 1.14.99.- Synonym: ttt 16 beta-hydroxylase (26 Jun 1999) |
| testosterone 17 beta-dehydrogenase | <enzyme> Catalyses reversibly the oxidation of testosterone to 4-androstene-3,17-dione in the presence of nad; was mapped to testosterone dehydrogenases (81-93) (see under 17-hydroxysteroid dehydrogenases (81-90); on-line search 17-hydroxysteroid dehydrogenases (81-93), index medicus see testosterone dehydrogenases (91-93) and 17-hydroxysteroid dehydrogenases (81-90) Registry number: EC 1.1.1.63 Synonym: 17 beta-hydroxysteroid-nad+ 17-oxidoreductase (26 Jun 1999) |
| testosterone 6-beta hydroxylase | <enzyme> Pcn2 is an allelic variant form (2 amino acid alterations); for cyp3a2, consider also lidocaine n-deethylase Registry number: EC 1.14.13.- Synonym: cytochrome p450(6 beta), cytochrome p-450 6b-1(pb1), cyp6b1, testosterone 6beta-hydroxylase, cyt p450 6beta-3, cytochrome p450(pcn2), 6beta-a gene product, cyp3a2, cyp6b3 (26 Jun 1999) |
| TGF-beta receptor protein kinase | <enzyme> Belongs to the receptor-type serine-threonine kinase subfamily; from chick embryo, related to type II receptor for tgf-beta; 502 aa residues, mw 56,766 da; aa sequence given in first source Registry number: EC 2.7.1.- Synonym: tgf-beta rpk, rpk-1, rpk-2 (26 Jun 1999) |
| thalassaemia, beta | Also known as thalassaemia major.The clinical picture of this important type of anaemia was first described in 1925 by the paediatrician thomas benton cooley. Other names for the disease are cooley's anaemia and mediterranean anaemia. The name thalassaemia was coined by the nobel prise winning pathologist george whipple and the professor of paediatrics wm bradford at u. Of rochester because thalassa in greek means the sea (like the mediterrranean sea) + -aemia means in the blood so thalassaemia means sea in the blood. Thalassaemia is not just one disease. It is a complex contingent of genetic (inherited) disorders all of which involve underproduction of haemoglobin, the indispensable molecule in red blood cells that carries oxygen. The globin part of normal adult haemoglobin is made up of 2 alpha and 2 beta polypeptide chains. In beta thalassaemia, there is a mutation (change) in both beta globin chains leading to underproduction (or absence) of beta chains, underproduction of haemoglobin, and profound anaemia. The gene for beta thalassaemia is relatively frequent in people of mediterranean origin (for example, from italy and greece). Children with this disease inherit one gene for it from each parent. The parents are carriers (heterozygotes) with just one thalassaemia gene, are said to have thalassaemia minor, and are essentially normal. Their children affected with beta thalassaemia seem entirely normal at birth because at birth we still have predominantly foetal haemoglobin which does not contain beta chains. The anaemia surfaces in the first few months after birth and becomes progressively more severe leading to pallor and easy fatiguability, failure to thrive (grow), bouts of fever (due to infections) and diarrhoea. Treatment based on blood transfusions is helpful but not curative. Gene therapy will, it is hoped, be applicable to this disease. (12 Dec 1998) |
| thiol beta-lactamase | <enzyme> Active site serine has been mutated to cysteine in e. Coli Registry number: EC 3.5.2.- (26 Jun 1999) |
| toroidal beta | <radiobiology> Plasma beta using the toroidal magnetic field, i.e. Plasma pressure divided by toroidal field pressure. See: beta. (09 Oct 1997) |
| endo-1,3-beta-xylanase | <enzyme> Cgxa and cgxb are from chaetomium Registry number: EC 3.2.1.32 Synonym: xylanase, xync protein, xync gene product, cgxa gene product, cgxb gene product (26 Jun 1999) |
| endo-1,4-beta-xylanase | <enzyme> From bacteria Registry number: EC 3.2.1.8 Synonym: endoxylanase, beta xylanase, xylanase z, pentosanase, xyna protein, xyna gene product, xylanase j, xlna gene product, xylanase y, xlny gene product, 1,4-beta-d-xylanohydrolase, xyn3 gene product, xylanase III (26 Jun 1999) |
| endo beta-(1-5)-galactofuranase | <enzyme> A glycoprotein, mr 77,000; an endozyme which hydrolyses internal galactoside linkages Registry number: EC 3.2.1.- Synonym: beta-(1-5)-galactofuranase (26 Jun 1999) |
| endo-beta-D-galactofuranosidase | <enzyme> Degrades beta(1-6) galactofuranoside linkages in the polysaccharide of fusarium sp. M7-1; do not confuse with blood-group-substance endo-1,4-beta-galactosidase (EC 3.2.1.102) and keratan-sulfate endo-1,4-beta-galactosidase (EC 3.2.1.103) both also called endo-beta-galactosidase Registry number: EC 3.2.1.- Synonym: endo-beta-galactofuranosidase (26 Jun 1999) |
| endo-beta-xylosidase | <enzyme> Found in rabbit liver lysosomes; proteoglycan linkage region-degrading enzyme Registry number: EC 3.2.1.- (26 Jun 1999) |
| transforming growth factor beta | Factor synthesised in a wide variety of tissues including platelets, placenta, and both normal and transformed cell lines. It acts synergistically with tgf-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. Tgf-beta also has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. There are at least three forms of tgf-beta: tgf-beta1, tgf-beta2, and tgf-beta1.2. The latter is a heterodimer made up of both tgf-beta1 and tgf-beta2. (12 Dec 1998) |