| protein-tyrosine kinase | <enzyme> An enzyme that catalyses the phosphorylation of tyrosine residues in proteins with ATP or other nucleotides as phosphate donors.12. Chemical name: ATP:protein-tyrosine O-phosphotransferase Registry number: EC 2.7.1.112 (12 Dec 1998) |
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| protein-tyrosine-phosphatase | <enzyme> An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with protein-tyrosine kinase, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. Chemical name: Protein-tyrosine-phosphate phosphohydrolase Registry number: EC 3.1.3.48 (12 Dec 1998) |
| protein Zero | <protein> The major glycoprotein of peripheral nerve myelin, an integral transmembrane protein, synthesised by Schwann cells (Mw = 28, 500). (18 Nov 1997) |
| proteolipid protein | <protein> Highly conserved membrane protein (30 kD) in myelin. Cellular function obscure but mutations lethal for example jimpy mouse and Pelizaeus Merzbacher disease of man. (18 Nov 1997) |
| proto-oncogene protein p21(ras) | Cellular protein encoded by the c-ras genes. The protein has GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia. (12 Dec 1998) |
| proto-oncogene protein pp60(c-src) | <enzyme> Membrane-associated tyrosine-specific kinase encoded by the c-src genes. It has an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to pp60(v-src) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase. Registry number: EC 2.7.1.- (12 Dec 1998) |
| heterologous protein | A protein that differs from any protein normally found in the organism in question. Synonym: heterologous protein. (05 Mar 2000) |
| prp 27-30 protein | Protease-resistant core of prpsc, the abnormal isoform of prion proteins (prions). Prp 27-30 is produced by limited proteolysis of the n-terminus of prpsc. (12 Dec 1998) |
| high-mobility group protein | <protein> An HMG protein is one of a group of various different proteins which are somehow involved with chromatin, but which are not histones and whose exact function is not known. (09 Oct 1997) |
| HIV core protein p24 | A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by elisa and western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines. (12 Dec 1998) |
| HIV envelope protein gp120 | External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120,000 kD and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably t4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV. (12 Dec 1998) |
| HIV envelope protein gp160 | An envelope protein of the human immunodeficiency virus that is encoded by the HIV env gene. It has a molecular weight of 160,000 kD and contains numerous glycosylation sites. It serves as a precursor for both the HIV envelope protein gp120 and the HIV envelope protein gp41. (12 Dec 1998) |
| HIV envelope protein gp41 | Transmembrane envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 41,000 and is glycosylated. The n-terminal part of gp41 is thought to be involved in cell fusion with the CD4 antigens of t4 lymphocytes, leading to syncytial formation. Gp41 is one of the most common HIV antigens detected by immunoblotting. (12 Dec 1998) |
| PTC protein | Formed by the reaction of phenylisothiocyanate with a terminal alpha-amino group of a peptide or protein See: phenylisothiocyanate, phenylthiohydantoin. Synonym: PhNCS protein, PTC protein. (05 Mar 2000) |
| hn protein | Glycoprotein from sendai, para-influenza, newcastle disease, and other viruses that participates in binding the virus to cell-surface receptors. The hn protein possesses both haemagglutinin and neuraminidase activity. (12 Dec 1998) |