| cis trans test | <molecular biology> The complementation test with two or more interacting genes placed in cis and in trans relationships to each other. A double mutant genome is used in the cis test made from the two single mutant genomes used in the trans test by recombination. If the wild type phenotype is restored by both cis and trans arrangements it is concluded that the two mutations are in different genes and hence that the phenotype is determined by more than one gene. If the trans test is negative and the cis positive this means that the two mutations are in the same gene. If both tests are negative then at least one of the mutations must be dominant. Thus the double test provides a means of fine mapping of genes. A lab test which is used to determine whether two mutations of different genes which affect the same phenotype are on the same functional unit (indicating a cis configuration of the mutated genes) or on different functional units (indicating a trans configuration of the mutated genes). (A functional unit can be a chromosome.) The test is done by mating an individual that has one of the mutations to an individual that has the other one, and observing whether their offspring have the mutant phenotype. If the offspring do not have the mutant phenotype, then the genes are known to be trans, because the offspring have normal copies of each mutant gene on the different functional units which are able to genetically complement each other. If the offspring do have the mutant phenotype, then the genes are known to be cis, because the offspring will always inherit at least one of the mutant genes on the one functional unit, resulting in the mutant phenotype. (09 Oct 1997) |
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| citric acid urine test | <investigation> A test which measures the amount of citric acid in the urine. This test is used to diagnose renal tubular acidosis and evaluate those with kidney stones. A below normal level of citric acid in the urine can indicate renal tubular acidosis. Urine citric acid levels can be increased in those with have a high carbohydrate diet, are on oestrogen therapy or vitamin D therapy. (27 Sep 1997) |
| milk-ring test | A special form of agglutination test done on the pooled milk of many cows, usually entire herds, for the detection of herds containing individuals infected with bovine brucellosis. (05 Mar 2000) |
| Millon Clinical Multiaxial Inventory test | A paper and pencil test, consisting of 20 clinical scales derived from 175 self-descriptive statements, and developed in 1977 for use in the assessment of psychopathology and the more enduring patterns of personality; specifically designed to correspond with some of the disorders of personality included in the Diagnostic and Statistical Manual of Mental Disorders used in diagnosis by mental health professionals. Synonym: Millon clinical multiaxial inventory. (05 Mar 2000) |
| Millon-Nasse test | A test for protein, the tyrosine of which reacts with nitrite after a brief treatment with mercuric ion in acid to give a colour. (05 Mar 2000) |
| Clauberg test | A test for progestational activity; immature rabbits are treated with 8 daily injections of oestrogen and then given 5 daily injections of the test substance; the amount required to produce definite progestational changes in the endometrium is taken as the unit; it is equivalent to 0.75 mg of progesterone. (05 Mar 2000) |
| photo-patch test | A test of contact photosensitization: after application of a patch with the suspected sensitiser for 48 hours to two sites, if there is no reaction one area is exposed to a weak erythema dose of sunlight or ultraviolet light; if positive, a more severe reaction with vesiculation develops at the exposed patch area than the nonexposed skin patch site. (05 Mar 2000) |
| Minnesota multiphasic personality inventory test | A questionnaire type of psychological test for ages 16 and over, with 550 true-false statements coded in 4 validity and 10 personality scales which may be administered in both an individual or group format. Synonym: Minnesota Multiphasic Personality Inventory. (05 Mar 2000) |
| photostress test | Measurement of visual acuity before and after exposure of the eyes to intense light. (05 Mar 2000) |
| phrenic pressure test | Pressure is made on the phrenic nerve on each side, above the clavicles where the nerve passes over the scalenus anticus muscle; if pain is felt and the patient inclines his head to the painful side, the problem is in the pleural space; if his head does not incline to one side, the problem is in the abdominal cavity. (05 Mar 2000) |
| clomiphene test | A test of pituitary gonadotropin reserve using clomiphene. (05 Mar 2000) |
| phthalein test | An obsolete test for renal function; after the patient has drunk a glass or two of water, 1 ml of a 0.6% solution of dye is injected hypodermically; the time between this injection and the appearance of a pink tinge in the urine as it falls into an alkaline solution is noted; the amount excreted in each of the next 2 hours is then estimated colourimetrically. Synonym: Geraghty's test, phthalein test, red test, Rowntree and Geraghty test. (05 Mar 2000) |
| mixed lymphocyte culture test | Measure of histocompatibility at the hl-a locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way mlc test, the lymphocytes from one of the individuals are inactivated (usually by treatment with mitomycin c or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens. (12 Dec 1998) |
| MLC test | Measure of histocompatibility at the hl-a locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way mlc test, the lymphocytes from one of the individuals are inactivated (usually by treatment with mitomycin c or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens. (12 Dec 1998) |
| CO2-withdrawal seizure test | Utilization of hyperventilation to demonstrate abnormalities in the brain waves or even to precipitate a convulsion. (05 Mar 2000) |