| NIA | National Institute on Aging; nephelometric inhibition assay; niacin; no information available; Nutri... |
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| OLA | left occipitoanterior [fetal position] [Lat. occipito-laeva anterior]; oligonucleotide ligation assa... |
| PRA | panel-reactive antibody; phosphoribosylamine; physician recognition award; plasma renin activity; pr... |
| PrA-HPA | protein A hemolytic plaque assay |
| REA | radiation emergency area; radioenzymatic assay; renal anastomosis; right ear advantage |
| tumour promoter | <molecular biology, oncology> Agent that in classical studies of carcinogenesis in rodent skin was able to increase the sensitivity of tumour formation by a previously applied primary carcinogen, but was unable to induce tumours when used alone. Important example was croton oil, active ingredients of which are now believed to be phorbol esters. These are believed to act as analogues of diacylglycerols and may activate protein kinase C. Strictly speaking, not the same as a co carcinogen, which is defined as being active when administered at the same time. Tumour promoters generally are carcinogens when tested more stringently. (18 Nov 1997) |
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| tumour registry | Recorded information about the status of patients with tumours. Although a registry was originally the place (like registry house in edinburgh) where information was collected (in registers), the word registry has also come to mean the collection itself. A tumour registry is organised so the data can be analyzed. For example, analysis of data in a tumour registry maintained at a hospital may show a rise in lung cancer among women. (12 Dec 1998) |
| tumour specific antigen | <immunology, oncology> Antigen on tumour cells detected by cell-mediated immunity. For virus transformed cells TSTA (unlike T antigen) is found to differ for different individual tumours induced by the same virus. May consist of fragments of T antigens exposed at the cell surface. (18 Nov 1997) |
| tumour-specific transplantation antigens | Surface antigen's of DNA tumour virus-transformed cells, which elicit an immune rejection of the virus-free cells when transplanted into an animal that has been immunised against the specific cell-transforming virus. (05 Mar 2000) |
| tumour stage | <oncology> The extent of the spread of a malignant neoplasm from its site of origin. See: TNM staging. (05 Mar 2000) |
| tumour suppressor | <molecular biology, oncology> A gene that encodes a product that normally negatively regulates the cell cycle and that must be mutated or otherwise inactivated before a cell can proceed to rapid division. Examples: p53, RB retinoblastoma), WT 1 (Wilm's tumour), DCC (deleted in colonic carcinoma), NF 1 (neurofibrosarcoma) and APC adenomatous polyposis coli). (18 Nov 1997) |
| tumour virus | <oncology, virology> Virus capable of inducing tumours. (18 Nov 1997) |
| tumour viruses, murine | Species of mammalian type c retroviruses (retroviruses type c, mammalian) that cause solid tumours or leukaemias in mice. (12 Dec 1998) |
| tumour virus infections | Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses. (12 Dec 1998) |
| turban tumour | Cylindroma of the scalp which, when overgrown, may resemble a turban. (05 Mar 2000) |
| Ewing's tumour | A malignant primary bone tumour that arises most commonly in the first three decades of life. It is highly malignant (prone to spread) and often requires treatment with some combination of radiation therapy and chemotherapy. (27 Sep 1997) |
| faecal tumour | An accumulation of inspissated faeces in the colon or rectum giving the appearance of an abdominal tumour. Synonym: faecal tumour, fecaloma, scatoma, stercoroma. Origin: copro-+ G. -oma, tumour (05 Mar 2000) |
| yaba monkey tumour virus | The type species of yatapoxvirus, a tumour-producing DNA virus discovered in monkeys in yaba, nigeria. It has been found to produce histiocytomas in monkeys and humans. (12 Dec 1998) |
| Yaba tumour | <oncology, virology> A poxvirus-induced neoplasm of African monkeys caused by the Yaba monkey virus, a member of the family Poxviridae. It is associated with tumour-like growths occur chiefly on the head and limbs. The tumours are benign and the natural disease has been reported only in Africa in monkeys kept outdoors. (05 Mar 2000) |
| yolk sac tumour | An unusual and aggressive tumour of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumour found in children. It is characterised by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (schiller-duval body). The tumour is rarely bilateral. Before the use of combination chemotherapy, the tumour was almost invariably fatal. (12 Dec 1998) |