| thymidine kinase | <enzyme> Of pyrimidine salvage, catalysing phosphorylation of thymine deoxyriboside to form its 5' phosphate, the nucleotide thymidylate. Animal cells lacking this enzyme can be selected by lethal synthesis, for example by resistance to bromodeoxyuridine and can be used as parentals in somatic hybridisation, since they are unable to grow in HAT medium. (18 Nov 1997) |
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| ectoprotein kinase | <enzyme> From outer plasma membranes; active site and substrate oriented extracellularly Registry number: EC 2.7.1.- Synonym: ecto-protein kinase, ectokinase (26 Jun 1999) |
| TIE-2 receptor tyrosine kinase | <enzyme> Expressed in developing vascular endothelial cells; unlike tie-1, also expressed in lens epithelium and heart epicardium; has the same organization of amino acid sequence motifs characteristic of tie-1; aa sequence of the intracellular and extracellular regions of tie-1 and tie-2 are 79% and 32% identical, respectively; aa sequence of both kinases given in first source Registry number: EC 2.7.10.- Synonym: tie-2-rtk (26 Jun 1999) |
| tie receptor tyrosine kinase | <enzyme> From human leukaemia cells; expressed in developing vascular endothelial cell; has homology with egf, bfgf, csf-1, pdgf and stem cell factor receptors; ligand and biologic function not known as of 12/92; tie-1 receptor tyrosine kinase is rat homolog of tie receptor tyrosine kinase; aa sequence known Registry number: EC 2.7.10.- Synonym: tie-1 receptor tyrosine kinase, tie-1 rtk (26 Jun 1999) |
| eif-2 kinase | <enzyme> A dsrna-activated camp-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsrna and ATP, eif-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyses the phosphorylation of the alpha subunit of eif-2, leading to the inhibition of protein synthesis. Registry number: EC 2.7.10.- (12 Dec 1998) |
| TNF-IL1-activated protein kinase | <enzyme> Phosphorylates beta casein in vitro; not the same as casein kinase 1 and casein kinase 2; not activated by mitogens, celllular stresses or any other cytokines than il1 and tnf Registry number: EC 2.7.1.- Synonym: tip kinase, beta casein kinase (26 Jun 1999) |
| emb protein-tyrosine kinase | <enzyme> Isolated from murine mast cells Registry number: EC 2.7.1- Synonym: emb ptk (26 Jun 1999) |
| emt protein-tyrosine kinase | <enzyme> Isolated from murine mast cells Registry number: EC 2.7.1.- Synonym: emt ptk, itk protein, itk gene product, tsk protein, inducible t cell kinase (26 Jun 1999) |
| epidermal growth factor receptor protein-tyrosine kinase | <enzyme> The catalytic protein-tyrosine kinase domain found on the cytoplasmic beta-portion of epidermal growth factor receptor. Registry number: EC 2.7.1.- (12 Dec 1998) |
| tropomyosin kinase | <enzyme> From chick embryo; requires mg; ca and cyclic AMP not needed Registry number: EC 2.7.1.132 (26 Jun 1999) |
| TTK kinase | <enzyme> Can phosphorylate serine, threonine and tyrosine hydroxyamino acids and is associated with cell proliferation; amino acid sequence given in first source Registry number: EC 2.7.10.- (26 Jun 1999) |
| estradiol receptor tyrosine kinase | <enzyme> Calcium and calmodulin dependent Registry number: EC 2.7.1.- Synonym: ertk (26 Jun 1999) |
| JNK-activating protein kinase | <enzyme> A dual specificity kinase that activates jun kinases and p38-mpk2; amino acid sequence given in first source Registry number: EC 2.7.1.- Synonym: jnk kinase, jnkk, hemipterous protein, hep protein, jun amino-terminal kinase kinase, jn kinase kinase, hep gene product (26 Jun 1999) |
| tyrosine kinase | <enzyme> Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand binding domain, a single transmembrane domain and an intracellular tyrosine kinase domain and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (18 Nov 1997) |
| tyrosyl tRNA synthetase kinase | <enzyme> From postribosomal supernatants of bom:nmri mouse liver; comigrates with tyrosyl trna synthetase during several purification steps Registry number: EC 2.7.1.- Synonym: tyr trna synthetase kinase (26 Jun 1999) |