| IRR | insulin receptor-related receptor; intrarenal reflux |
|---|---|
| IRS | immunoreactive secretion; infrared spectrophotometry; insulin receptor species; insulin receptor sub... |
| HNF1A | hepatocyte nuclear factor-1-alpha |
| NGFA | nerve growth factor alpha |
| TGFA | transforming growth factor alpha; triglyceride fatty acid |
| alpha thalassaemia | <haematology> A condition characterised by the reduced synthesis of the alpha chain of haemoglobin due to abnormality in one of two or more genes that code for the synthesis of alpha-globin chains. The severity of this condition can vary from mild anaemia to death, depending on the number of genes deleted. Heterozygous state: severe type, thalassaemia minor with 5 to 15% of Hb Barts at birth, only traces of Hb Barts in adult; mild type, 1 to 2% of Hb Barts at birth, not detectable in adult. Homozygous state: severe type, erythroblastosis foetalis and foetal death, only Hb Barts and Hb H present; mild type not clinically defined. See: haemoglobin H. (05 Mar 2000) |
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| alpha-tocopherol | <chemical> A light yellow, viscous, odourless, oily liquid that deteriorates on exposure to light, is obtained from wheat germ oil or by synthesis, biologically exhibits the most vitamin E activity of the alpha-tocopherol's, and is an antioxidant retarding rancidity by interfering with the autoxidation of fats. Prepared from natural phytol, it is called 2-ambo-alpha-tocopherol; from synthetic phytol, all-rac-alpha-tocopherol or synt-alpha-tocopherol; also available are d-alpha-tocopheryl acetate, dl-alpha-tocopheryl acetate, d-alpha-tocopheryl acid succinate, and d-alpha-tocopheryl acetate concentrate. One of several forms of vitamin E. Chemical name: 2,5,7,8-tetramethyl-2-(4',8',12'-trimeth yltridecyl)-6-chromanol; 5,7,8-trimethyltocol Synonym: vitamin E. (14 Aug 2000) |
| alpha-tubulin acetylase | <enzyme> From chlamydomonas flagella; catalyses the acetylation of alpha-tubulin-l-lysine in the presence of acetyl-CoA to yield CoA and alpha-tubulin n(epsilon)-acetyl-l-lysine Registry number: EC 2.3.1.108 Synonym: alpha-tubulin acetyltransferase (26 Jun 1999) |
| alpha units | Cytoplasmic glycogen granules arranged in rosettes. (05 Mar 2000) |
| alpha viruses | <virology> These are the major viruses in the Togavirus group and include eastern and western equine encephalitis viruses, the Sindbis virus and the Semliki Forest virus. The last two viruses are being researched as vectors for expressing heterologous genes. (09 Oct 1997) |
| alpha wave | Brain waves in the encephalogram which have a frequency of 8 to 13 per second. They are typical of the normal person awake and in a quiet resting state, and occur principally in the occipital region. (12 Dec 1998) |
| androstenedione 17-alpha-oxidoreductase | <enzyme> Forms epitestosterone; was mapped to testosterone dehydrogenases (85-93); index medicus see under 17-hydroxysteroid dehydrogenases (85-90) Registry number: EC 1.1.1.- Synonym: steroid 17alpha oxidoreductase, androstenedione 17-oxidoreductase (26 Jun 1999) |
| aryl-alpha-mannosidase | <enzyme> Act on p-nitrophenyl-alpha-d-mannopyranoside Registry number: EC 3.2.1.- Synonym: aryl-alpha-mannosidase a, aryl-alpha-mannosidase b (26 Jun 1999) |
| aspartate-alpha-decarboxylase | <enzyme> Forms beta-alanine Registry number: EC 4.1.1.11 Synonym: aspartate 1-decarboxylase (26 Jun 1999) |
| beta-D-galactoside alpha 2-6-sialyltransferase | <enzyme> Catalyses the reaction of cmp-n-acetylneuraminate and galactosylglycoprotein to yield cmp and n-acetylneuraminylgalactosylglycoprotein; cd75 and cd75w antigen were removed as sys - it is not equivalent to the enzyme. Registry number: EC 2.4.99.1 Synonym: cmp-n-acetylneuraminate-d-galactosyl-glycoprotein n-acetylneurainyltransferase, cmp-n-acetylneuraminate-beta-galactoside alpha-2,6-sialyltransferase, beta-galactosyl(1-4)n-acetylglucosaminide alpha(2-6)-sialyltransferase, gal-glcnac(2-6)-sialyltransferase, cmp-n-acetylneuraminic acid-lactose sialytransferase, cmp-acetylneuraminate galactoside (alpha 2-6)-sialyltransferase, cmp-n-acetylneuraminate-galactosylglycoprotein sialyltransferase, alpha 2-6-sialyltransferase, cmp-sialic acid-n-acetyllactosaminide alpha (2-6)-sialyltransferase, cmp-neuac-galactoside (alpha 2-6)-sialyltransferase, gal-1-4-glcnac alpha(2-6)-sialyltransferase, siat-1, beta-galctoside alpha2,6-sialyltransferase (26 Jun 1999) |
| beta-galactoside alpha-2,3-sialyltransferase | <enzyme> Transfers sialic acid residue from cmp-n-acetylneuraminic acid to an acceptor galactoside Registry number: EC 2.4.99.4 Synonym: alpha 2-3-sialyltransferase, cmp-neuac-galactoside (alpha 2-3)-sialyltransferase, cmp-angs-transferase, cmp n-acetylneuraminate-beta-galactoside alpha-2,3-sialyltransferase, cmpsialic acid beta-galactosyl-1-3-n-acetylgalactosaminide alpha 2-3-sialyltransferase, beta-d-galactoside 3-alpha-sialyltransferase, cmp-acetylneuraminate-galactoside (alpha 2-3)-sialyltransferase, asialofetuin sialyltransferase, gal beta1,3galnac alpha2,3-sialyltransferase, cmp-neu5ac-gal beta1-3galnac alpha-2,3-sialyltransferase, cmp-neu5ac-gal1-3galnac alpha-2,3-sialyltransferase, alpha-2,3-st(o) (26 Jun 1999) |
| beta-galactosyl(1-3)N-acetylglucosaminide alpha(2-3)-sialyltransferase | <enzyme> Found in rat liver golgi apparatus Registry number: EC 2.4.99.- Synonym: gal-1-3-glcnac-sialyltransferase (26 Jun 1999) |
| beta-glucosyl-hydroxymethylcytosine-alpha-glucosyltransferase | <enzyme> Generates gentobiosyl groups on the hydroxymethylcytosine of phage t2 and t6 DNA Registry number: EC 2.4.1.- Synonym: b-glc-hmc-a-glucosyltransferase (26 Jun 1999) |
| bile acid 7 alpha-dehydroxylase | <enzyme> Mechanism is questionable: cholic acid - deoxycholic acid - chenodeoxycholic acid - lithocholic acid Registry number: EC 1.14.- Synonym: 7 alpha-dehydroxylase, bile acid 7-dehydroxylase, bile acid 7-alpha-dehydroxylase, bai a1, bai a2, bai a3, cholic acid 7alpha-dehydroxylase (26 Jun 1999) |
| galactosyl(alpha 1-4)galactosylceramide galactosyl hydrolase | <enzyme> Active in pH 3.0 component of human plasma (pn-a-2); greatly decreased in fabry's disease Registry number: EC 3.2.1.- Synonym: digalactosylceramidase (26 Jun 1999) |