| gene rearrangement, b-lymphocyte, heavy chain | Ordered rearrangement of b-lymphocyte variable gene regions thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the immature b-lymphocyte. (12 Dec 1998) |
|---|---|
| gene rearrangement, b-lymphocyte, light chain | Ordered rearrangement of b-lymphocyte variable gene regions coding for the kappa or lambda light chains, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the immature b-lymphocyte. (12 Dec 1998) |
| gene rearrangement, t-lymphocyte | Ordered rearrangement of T-cell variable gene regions coding for the antigen receptors. (12 Dec 1998) |
| gene redundancy | A situation in which many copies of the same gene exist in a genome. (09 Oct 1997) |
| gene regulation | The DNA and protein interactions in a gene that determine the temporal and spatial modes of expression as well as the amplitude of expression. (14 Nov 1997) |
| gene regulatory protein | <molecular biology> Any protein that interacts with DNA sequences of a gene and controls its transcription. (18 Nov 1997) |
| gene sequencing | Determination of the sequence of nucleotide bases in a strand of DNA. (14 Nov 1997) |
| gene splicing | A procedure by which one DNA molecule or fragment can be attached to another. (14 Nov 1997) |
| gene supression | <molecular biology> The halting of abnormal gene activity which results in the restoration of lost or impaired genetic function. (09 Oct 1997) |
| mapping, gene | Charting the positions of genes on chromosome and learning the distance, in linkage units or physical units, between genes. (12 Dec 1998) |
| gene switch | <molecular biology> A situation in which a cell or organism stops expressing one gene orgene group and switches to expressing a different gene or group of genes. (09 Oct 1997) |
| gene synthesis | <molecular biology> The complete synthesis of a gene using a DNA synthesiser (gene machine), or the assembly of oligonucleotides so synthesised into a synthetic gene, as opposed to cloning. (14 Nov 1997) |
| gene targeting | The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination. (12 Dec 1998) |
| gene testing | Testing a sample of blood (or another fluid or tissue) for evidence of a gene. The evidence can be biochemical, chromosomal, or genetic. The aim is to learn whether a gene for a disease is present or absent. (12 Dec 1998) |
| gene transfer | <molecular biology> General tem for the insertion of foreign genes into a cell or organism. Synonymous with transfection. (18 Nov 1997) |