| canavan disease | Spongy degeneration of cerebral white matter, a rare autosomal recessive form of leukodystrophy. It is characterised by early onset, widespread demyelination and vacuolation of the white matter that gives rise to a spongy appearance, severe mental retardation, megalocephaly, atony of the neck muscles, spasticity of the extremities, and blindness. Death occurs at about 18 months of age. (12 Dec 1998) |
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| Canavan's disease | Autosomal recessive degenerative disease of infancy; mostly in Jewish infants; onset typically within first 3-4 months of birth, consisting of blindness, psychomotor regression, enlarged head, optic atrophy, hypotonia, spasticity, increased N-acetylaspartic acid urinary excretion. MRI shows enlarged brain, decreased attenuation of cerebral and cerebellar white matter, and normal ventricles. Pathologically, there is increased brain volume and weight, and spongy degeneration in the subcortical white matter. See: leukodystrophy. Synonym: Canavan's sclerosis, Canavan-van Bogaert-Bertrand disease, spongy degeneration of infancy. (05 Mar 2000) |
| Canavan-van Bogaert-Bertrand disease | Autosomal recessive degenerative disease of infancy; mostly in Jewish infants; onset typically within first 3-4 months of birth, consisting of blindness, psychomotor regression, enlarged head, optic atrophy, hypotonia, spasticity, increased N-acetylaspartic acid urinary excretion. MRI shows enlarged brain, decreased attenuation of cerebral and cerebellar white matter, and normal ventricles. Pathologically, there is increased brain volume and weight, and spongy degeneration in the subcortical white matter. See: leukodystrophy. Synonym: Canavan's sclerosis, Canavan-van Bogaert-Bertrand disease, spongy degeneration of infancy. (05 Mar 2000) |
| cancer, hodgkin's disease | A type of lymphoma (cancer of the lymphatic system). The most common symptom of Hodgkin's disease is a painless swelling in the lymph nodes in the neck, underarm, or groin. Hodgkin's disease is diagnosed when abnormal tissue is detected by a pathologist after a biopsy of an enlarged lymph node. Treatment usually includes radiation therapy or chemotherapy. Regular follow-up examinations are important after treatment for Hodgkin's disease. Patients treated for Hodgkin's disease have an increased risk of developing other types of cancer later in life, especially leukaemia. (12 Dec 1998) |
| canine parvovirus disease | An acute disease of dogs with a variable mortality rate caused by the canine parvovirus; seen in three distinct clinical forms; a generalised neonatal disease, a severe nonsuppurative myocarditis, and a frequently fatal enteritis. (05 Mar 2000) |
| carcinoid heart disease | Cardiac manifestation of malignant carcinoid syndrome. It is a unique form of fibrosis involving the endocardium, primarily of the right heart. The fibrous deposits tend to cause constriction of the tricuspid and pulmonary valves. (12 Dec 1998) |
| caroli disease | <radiology> Communicating, cavernous ectasia of the intrahepatic bile ducts, rare, autosomal recessive, usually detected in young adults, no cirrhosis or portal hypertension, predisposed to calculus formation, benign course, but.. Recurrent cholangitis most likely to be liver abscesses most likely to be death, associated with medullary sponge kidney (renal tubular ectasia) in 80% (12 Dec 1998) |
| caroli's disease | Congenital cystic dilatation of the intrahepatic bile ducts. It consists of 2 types: simple, with bile duct dilatation or ectasia alone, and complex, with associated extensive hepatic fibrosis and portal hypertension. Benign renal tubular ectasia is associated with both types. (12 Dec 1998) |
| rabbit haemorrhagic disease | A highly infectious disease of rabbits, caused by a calicivirus and characterised by haemorrhagic lesions, particularly affecting the lungs and liver; since it was first identified in China in 1984, it has been reported from Korea, it has spread through Europe, and it has reached North Africa and Mexico. (05 Mar 2000) |
| machado-joseph disease | A progressive degenerative disease of the central nervous system occurring in portuguese-azorean families, having a variety of forms and inherited as an autosomal dominant trait. There are four major types: type I: with pyramidal and extrapyramidal deficits; type II: with cerebellar, pyramidal and extrapyramidal deficits; type III: with cerebellar deficits and distal sensorimotor neuropathy; type IV: with parkinsonism and distal sensory neuropathy. It was originally reported in two portuguese-azorean families in massachusettes (machado), then in another portuguese family (thomas), and later in a third family in california (joseph, who settled there in 1845). It has been reported also in japanese families. (12 Dec 1998) |
| Paas' disease | A familial skeletal deformation marked by coxa valga, double patella, shortening of the middle and terminal phalanges of fingers and toes, deformities of the elbows, scoliosis, and spondylitis deformans of the lumbar vertebrae; all of these manifestations may be unilateral or bilateral. (05 Mar 2000) |
| Gairdner's disease | <disease> Attacks of cardiac distress accompanied by apprehension. Synonym: angina pectoris sine dolore, angor pectoris. (05 Mar 2000) |
| Pacheco's disease | A highly contagious, acute disease of psittacine birds caused by a herpesvirus and characterised by bright yellow urates with scant faeces, icterus, and terminal anorexia. (05 Mar 2000) |
| Pacheco's parrot disease virus | Probably a virus of the family Herpesviridae, possibly related to the virus of infectious laryngotracheitis. Synonym: parrot virus. (05 Mar 2000) |
| vagabond's disease | Excoriations and melanoderma caused by scratching the bites of the body louse, Pediculus corporis. Synonym: Greenhow's disease, vagabond's disease, vagrant's disease. Racial melanoderma, the normally dark skin of blacks and certain other races. Senile melanoderma, cutaneous pigmentation occurring in the aged. Synonym: melasma universale. (05 Mar 2000) |