| carcinoma, adrenal cortical | A malignant neoplasm of adrenal cortical cells demonstrating partial or complete histological and functional differentiation. They are rare, comprising between only 0.05% and 0.2% of all cancers. Women develop functional adrenal cortical carcinomas more commonly than men, but men develop nonfunctioning ones more often than women. Hypercortisolism is the most common presentation for this cancer. Virilism and cushing's syndrome may also result. (12 Dec 1998) |
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| carcinoma, basal cell | A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (12 Dec 1998) |
| carcinoma, basosquamous | A skin carcinoma that histologically exhibits both basal and squamous elements. (12 Dec 1998) |
| carcinoma, bronchogenic | A cancer of the lung, so-called because it arises from the epithelium of the bronchial tree. It is not a histologic designation despite the name. (12 Dec 1998) |
| carcinoma, ehrlich tumour | A transplantable, poorly differentiated malignant tumour which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms. (12 Dec 1998) |
| carcinoma, embryonal | A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumours. (12 Dec 1998) |
| carcinoma, endometrioid | Ovarian carcinoma which resembles typical carcinoma of the endometrium and may be seen with a synchronous endometrial carcinoma. When they appear together, both tend to be of low stage. (12 Dec 1998) |
| carcinoma, giant cell | An epithelial neoplasm characterised by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (12 Dec 1998) |
| carcinoma, hepatocellular | Primary carcinoma of the liver cells. It ranges from a well-differentiated tumour difficult to distinguish from normal hepatocytes to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic or may form giant cells. Several classification schemes have been suggested. Hepatocellular carcinoma is very rare in the united states and western europe, but it is one of the most common cancers in eastern asia and sub-saharan africa. The cases are preponderantly male and, racially, whites have the lowest rates. (12 Dec 1998) |
| carcinoma, infiltrating duct | An invasive (infiltrating) carcinoma of the breast. This carcinoma in which no special histological feature is recognised is designated nos or not otherwise specified and is by far the most common ductal tumour, accounting for almost 70% of breast cancers. It is characterised by stony hardness upon palpation. It commonly metastasizes to the axillary lymph nodes and its prognosis is the poorest of the various ductal types. (12 Dec 1998) |
| carcinoma, intraductal, noninfiltrating | A noninvasive (noninfiltrating) carcinoma of the breast characterised by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma. Its true incidence is uncertain but all noninvasive breast carcinomas comprise almost 5% of all neoplastic lesions of the female breast, with this carcinoma accounting for about 50% of these, or 2.5%-2.8% of all tumours. (12 Dec 1998) |
| carcinoma, islet cell | A carcinoma of the islets of langerhans. (12 Dec 1998) |
| carcinoma, large cell | A tumour of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (12 Dec 1998) |
| carcinoma, lewis lung | A carcinoma discovered by dr. Margaret r. Lewis of the wistar institute in 1951. This tumour originated spontaneously as a carcinoma of the lung of a c57bl mouse. The tumour does not appear to be grossly haemorrhagic and the majority of the tumour tissue is a semifirm homogeneous mass. It is also called 3ll and llc and is used as a transplantable malignancy. (12 Dec 1998) |
| carcinoma, lobular | A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumours in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (12 Dec 1998) |