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malarial hyperreactive spleen s. a syndrome of massive splenomegaly, hepatomegaly, anemia, and elevated serum IgM levels that occurs in some areas where malaria is endemic, such as parts of sub-Saharan Africa and New Guinea. Lymphocytic infiltrates are present in hepatic sinusoids, and the association with chronic malarial infection is suggested by a polyclonal increase in IgM, a very high titer of IgM antibodies to Plasmodium falciparum, and often by a therapeutic response to malarial chemoprophylaxis. Called also tropical splenomegaly and tropical splenomegaly s.
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malarial p. Plasmodium.
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malarial s. the finely granular appearance often seen in stained erythrocytes that harbor tertian malarial parasites; see Maurer's s. and Schüffner's s.
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malariologist a person versed in or engaged in the study of malaria.
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malariology the study of malaria.
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