| thymus-independent antigen | An antigen that does not require T helper cell activation in order for the host's B-cells to be stimulated. Repeating polymers such as polysaccharides are examples of T-independent antigens. (05 Mar 2000) |
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| tissue polypeptide antigen | Serological tumour marker composed of a molecular complex of cytokeratins 8, 18, and 19. It is used in the diagnosis and staging of bronchogenic carcinoma. (12 Dec 1998) |
| tissue-specific antigen | A heterogenetic antigen with organ specificity; e.g., in addition to species-specific antigen, kidney of one species contains antigen that is identical to that in kidney of other species. Synonym: tissue-specific antigen. (05 Mar 2000) |
| TL antigen | <immunology> The mouse antigens coded for by the TLa complex, in normal animals only found on intrathymic lymphocytes, but also seen on leukaemic cells (hence, thymus leukaemia antigen) in certain forms of the disease in mice. The molecules have structures similar in some ways to Class I MHC products but are disulphide bonded tetramers of two 45 kD chains and two 12 kD chains of _2 microglobulin type. (18 Nov 1997) |
| transplantation antigen | <immunology> Any antigen that is antigenically active in graft rejection. In practice the major histocompatibility complex and the H Y antigens and to a lesser extent minor histocompatibility antigens. (18 Nov 1997) |
| Epithelial membrane antigen | <cell biology> Heavily glycosylated membrane glycoprotein. Encoded by the MUC 1 gene, has a molecular weight of around 300 kD, more than half of which is O linked glycan. There is a 69 residue cytoplasmic domain and the extracellular domain may extend hundreds of nanometres beyond the plasma membrane, the increased expression in carcinoma cells may reduce the adhesion and mask antigenic properties of the cells. Similar functions are ascribed to ASGP, epiglycanin and leucosialin. (18 Nov 1997) |
| tumour-associated antigen | Antigens that are highly correlated with certain tumour cells. They are not usually found, or are found to a lesser extent, on normal cells. (05 Mar 2000) |
| tumour specific antigen | <immunology, oncology> Antigen on tumour cells detected by cell-mediated immunity. For virus transformed cells TSTA (unlike T antigen) is found to differ for different individual tumours induced by the same virus. May consist of fragments of T antigens exposed at the cell surface. (18 Nov 1997) |
| Js antigen | sutter Blood Group |
| K antigen | Capsular antigens of bacteria usually polysaccharide. (18 Nov 1997) |
| Fas antigen | <protein> Cell surface transmembrane protein (35 kD) that mediates apoptosis. Has structural homology with TNF receptor and NGF receptor. May play a part in negative selection of autoreactive T-cells in the thymus. (18 Nov 1997) |
| ki-67 antigen | A cell cycle and tumour growth marker which can be readily detected using immunocytochemistry methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells. (12 Dec 1998) |
| Km antigen | Allotypic antigens that are present on human kappa immunoglobulin light chains. Synonym: InV group antigen. (05 Mar 2000) |
| Kveim antigen | A saline suspension of human sarcoid tissue prepared from the spleen of an individual with active sarcoidosis; used in the Kveim test. Synonym: Kveim-Stilzbach antigen. (05 Mar 2000) |
| Kveim-Stilzbach antigen | A saline suspension of human sarcoid tissue prepared from the spleen of an individual with active sarcoidosis; used in the Kveim test. Synonym: Kveim-Stilzbach antigen. (05 Mar 2000) |