| receptors, leukocyte-adhesion | Family of proteins associated with the capacity of leukocytes, including lymphocytes, monocytes, and neutrophils, to adhere to each other and to certain substrata, e.g., the c3bi component of complement. Members of this family are the lymphocyte function-associated antigen-1 (lfa-1), the macrophage-1 antigen (mac-1), and the antigen p150,95 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited leukocyte-adhesion deficiency syndrome, which is characterised by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells. (12 Dec 1998) |
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| receptors, leukotriene | Cell-surface receptors that bind leukotrienes with high affinity and trigger intracellular changes influencing the behaviour of cells. The leukotriene receptor subtypes have been tentatively named according to their affinities for the endogenous leukotrienes ltb4, ltc4, ltd4, and lte4. (12 Dec 1998) |
| receptors, leukotriene b4 | A class of cell surface leukotriene receptors with a preference for leukotriene b4. Leukotriene b4 receptor activation influences chemotaxis, chemokinesis, adherence, enzyme release, oxidative bursts, and degranulation in polymorphonuclear leukocytes. There are at least two subtypes of these receptors. Some actions are mediated through the inositol phosphate and diacylglycerol second messenger systems. (12 Dec 1998) |
| receptors, lh | Those protein complexes or molecular sites on the surfaces and cytoplasm of gonadal cells that bind luteinizing or chorionic gonadotropic hormones and thereby cause the gonadal cells to synthesise and secrete sex steroids. The hormone-receptor complex is internalised from the plasma membrane and initiates steroid synthesis. (12 Dec 1998) |
| receptors, lhrh | Receptors with a 6-kD protein on the surfaces of cells that secrete lh or fsh, usually in the adenohypophysis. Lhrh binds to these receptors, is endocytosed with the receptor and, in the cell, triggers the release of lh or fsh by the cell. These receptors are also found in rat gonads. Inhibin prevents the binding of gnrh to its receptors. (12 Dec 1998) |
| receptors, lipoprotein | Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognise the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis. (12 Dec 1998) |
| receptors, lymphocyte homing | Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to specialised blood vessels called high endothelial venules. Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface molecules (addressins) on high endothelial venules in different tissues. The adhesion plays a crucial role in the trafficking of lymphocytes. (12 Dec 1998) |
| receptors, macrophage colony-stimulating factor | Glycoproteins of mw 165 kD which are encoded by the c-fms proto-oncogene. The binding of csf-1 to its receptors activates an intrinsic tyrosine kinase activity resulting in autophosphorylation of the receptors on tyrosine, rapid receptor down-regulation, and phosphorylation of as yet unidentified physiologic substrates that initiate a mitogenic response. (12 Dec 1998) |
| receptors, metabotropic glutamate | Cell surface proteins that bind glutamate and act through g-proteins to influence second messenger systems. Several types of metabotropic glutamate receptors have been cloned. They differ in pharmacology, distribution, and mechanisms of action. (12 Dec 1998) |
| receptors, mineralocorticoid | Cytoplasmic proteins that specifically bind mineralocorticoids and mediate their cellular effects. The receptor with its bound ligand acts in the nucleus to induce transcription of specific segments of DNA. Mineralocorticoids were named for their actions on extracellular electrolyte concentrations. The most important example is aldosterone. (12 Dec 1998) |
| receptors, mitogen | Glycoprotein molecules on the surface of b- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes. (12 Dec 1998) |
| receptors, muscarinic | One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for muscarine over nicotine. There are several subtypes (usually m1, m2, m3...) that are characterised by their cellular actions, pharmacology, and molecular biology. (12 Dec 1998) |
| receptors, n-methyl-d-aspartate | A class of ionotropic glutamate receptors characterised by affinity for n-methyl-d-aspartate. Nmda receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity. (12 Dec 1998) |
| receptors, nerve growth factor | Cell surface receptors that bind nerve growth factor (ngf) and trigger intracellular changes influencing the behaviour of cells. Nerve growth factor receptors mediate the effects of nerve growth factor on the survival and growth of neurons. (12 Dec 1998) |
| receptors, neurokinin-1 | A class of cell surface receptors for tachykinins with a preference for substance p. Neurokinin-1 (nk-1) receptors have been cloned and are members of the G-protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells. (12 Dec 1998) |
Synonyms : GP80-LNGFR, Neurotrophin Receptor p75, Neurotropin Receptor p75, gp75 NGFR, p75 Neurotrophin Receptor, GP80 LNGFR, NGFR, gp75, Nerve Growth Factor Receptor, Low Affinity, Neurotrophin Receptor, p75, Receptor p75, Neurotrophin, Receptor p75, Neurotropin
Synonyms : Notch1 Protein
Synonyms : Notch2 Protein
Synonyms : PAR1 Receptor, Proteinase-Activated Receptor 1, PAR 1 Receptor, Protease Activated Receptor 1, Proteinase Activated Receptor 1, Receptor, PAR 1, Receptor, PAR1
Synonyms : PAR2 Receptor, Protease-Activated Receptor 2, Receptor, Trypsin, Trypsin Receptor, Trypsin Receptors, PAR 2 Receptor, Protease Activated Receptor 2, Receptor 2, Protease-Activated, Receptor, PAR 2, Receptor, PAR2, Receptors, Trypsin
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| reinforcement |
support: a military operation (often involving new supplies of men and materiel) to strengthen a military force or aid in the performance of its mission; "they called for artillery support" information that makes more forcible or convincing; "his gestures provided eloquent reinforcement for his complaints" reinforcing stimulus: (psychology) a stimulus that strengthens or weakens the behavior that produced it strengthener: a device designed to provide additional strength; "the cardboard backing was just a strengthener"; "he used gummed reinforcements to hold the page in his notebook" reward: an act performed to strengthen approved behavior
Ãâó: wordnet.princeton.edu/perl/webwn
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| resistant |
immune: relating to or conferring immunity (to disease or infection) tolerant: able to tolerate environmental conditions or physiological stress; "the plant is tolerant of saltwater"; "these fish are quite tolerant as long as extremes of pH are avoided"; "the new hybrid is more resistant to drought" impervious to being affected; "resistant to the effects of heat"; "resistant to persuasion" insubordinate: disposed to or engaged in defiance of established authority repellent: incapable of absorbing or mixing with; "a water-repellent fabric"; "plastic highly resistant to steam and water"
Ãâó: wordnet.princeton.edu/perl/webwn
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| rectified |
having been put right
Ãâó: wordnet.princeton.edu/perl/webwn
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| refractory anemia |
any of various anemic conditions that are not successfully treated by any means other than blood transfusions (and that are not associated with another primary disease)
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| recapitulation |
palingenesis: emergence during embryonic development of various characters or structures that appeared during the evolutionary history of the strain or species (music) the section of a composition or movement (especially in sonata form) in which musical themes that were introduced earlier are repeated a summary at the end that repeats the substance of a longer discussion
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| RE | an immunoglobulin E that is formed as an antibody against allergens (such as pollen) |
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| RE | an old small silver Spanish coin |
| RE | any rational or irrational number |
| RE | possible to be treated as fact |
| RE | having substance or capable of being treated as fact |
| RE | not synthetic or spurious |
| RE | being or occurring in fact or actuality |
| RE | no less than what is stated |
| RE | (economics) being value measured in terms of purchasing power |
| RE | founded on practical matters |
| RE | coinciding with reality |
| RE | not to be taken lightly |
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