| lethal gene | A gene that produces a genotype that leads to death of the organism before reproduction is possible or that precludes reproduction; for a recessive gene the homozygous or hemizygous state is lethal. (05 Mar 2000) |
|---|---|
| fushi tarazu gene | <molecular biology> A gene found in the fruit fly Drosophila melanogaster. Normal fruit fly embryos look like a series of stacked discs, which are called segments. Each segment eventually develops into specific adult fly structures (wings, antennae, legs, eyes, etc.) Flies which have a mutant form of the ftz gene are missing every other segment. (05 Jan 1998) |
| fusion gene | <molecular biology> A hybrid gene created by joining portions of two different genes (to produce a new protein) or by joining a gene to a different promoter (to alter or regulate gene transcription). (05 Jan 1998) |
| linked gene | <genetics> Genes and / or markers that are so closely associated on the chromosome that they are inherited together in 80% or more of cases. (14 Oct 1997) |
| acetyl-CoA:alpha-glucosaminide acetyltransferase | <enzyme> An enzyme involved in the synthesis of certain carbohydrate moieties on proteins. A deficiency of this enzyme leads to mucopolysaccharidosis type III C. (05 Mar 2000) |
| adrenergic alpha-agonists | Drugs that selectively bind to and activate alpha adrenergic receptors. (12 Dec 1998) |
| adrenergic alpha-antagonists | Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (12 Dec 1998) |
| alpha | First letter of the Greek alphabet, a. (05 Mar 2000) |
| alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase | <enzyme> Incorporates n-acetyglucosamine as the third branch of complex n-glycosyl-oligosaccharide of hen oviduct Registry number: EC 2.4.1.145 Synonym: glcnac-transferase iv, n-acetylglucosaminyltransferase iv, udp-glcnac-gngn(glcnac to man alpha1-3)beta 4-n-acetylglucosaminyltransferase iv (26 Jun 1999) |
| alpha-1,4-glucan lyase | <enzyme> Degrades alpha-1,4-glucan to produce 1,5-anhydrofructose; from seaweeds gracilariopsis lemaneiformis and gracilaria verrucosa; mw 111 kD; amino acid sequence has been determined Registry number: EC 4.2.2.- Synonym: alpha-1,4-glucan 4-lyase (26 Jun 1999) |
| alpha 1-4-mannosyltransferase | <enzyme> From mycobacterium smegmatis; involved in methylmannose polysaccharide elongation; GDP-mannose is donor Registry number: EC 2.4.1.- (26 Jun 1999) |
| alpha(1-6)mannosidase | <enzyme> Human lysosomal enzyme highly specific for alpha 1-6 mannose residues; inhibited by swainsonine; not the same enzyme which is deficient in alpha-mannosidosis Registry number: EC 3.2.1.- (26 Jun 1999) |
| alpha 1,6-mannosyltransferase | <enzyme> From saccharomyces cerevisiae; adds mannose residues in an alpha-1,6-linkage to man8glcnac and man9glcnac in the biosynthesis of the outer chain of yeast mannoproteins Registry number: EC 2.4.1.- (26 Jun 1999) |
| alpha-1 antichymotrypsin | <chemical> Glycoprotein found in alpha(1)-globulin region in human serum. It is an inhibiter of the digestive protease, chymotrypsin and other chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumour marker. It is a member of the serpin superfamily. Pharmacological action: serine proteinase inhibitors. (12 Dec 1998) |
| alpha-1 antitrypsin | <chemical> Plasma glycoprotein member of the serpin superfamily which inhibits trypsin, neutrophil elastase, and other proteolytic enzymes. Commonly referred to as alpha 1-proteinase inhibitor (a1pi), it exists in over 30 different biochemical variant forms known collectively as the pi (protease inhibitor) system. Hereditary deficiency is associated with pulmonary emphysema. See: alpha-1 antitrypsin deficiency Pharmacological action: serine proteinase inhibitors, trypsin inhibitors. (12 Dec 1998) |