| immunoglobulins, lambda-chain | One of the light chains of the immunoglobulins with a molecular weight of approximately 22 kD. They constitute about 40% of all light chains and can be recognised serologically as well as by their specific amino acid sequence. (12 Dec 1998) |
|---|---|
| immunoglobulins, light-chain | Polypeptide chains, consisting of 211 to 217 amino acid residues, isolated from immunoglobulins and having a molecular weight of approximately 22 kD. There are two major types of light chains, kappa and lambda. In man they are found in a ratio of 60% to 40%, respectively. Both chains consist of linear repeating, similar, but not identical, segments of about 110 amino acid residues. In each segment a disulfide bond establishes a tightly folded approximately 60-membered loop or domain. Adjacent domains are linked by less tightly folded regions. Both light chains contain two such domains. Two light and two heavy chains make one immunoglobulin molecule, but both light chains in one ig are of the same type. (12 Dec 1998) |
| immunoglobulins, mu-chain | Heavy chains found in the fab and fc fragments of IgM and having a molecular weight of approximately 72 kD. They contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IgG. (12 Dec 1998) |
| immunoglobulins, surface | Immunoglobulins bound to the surface of lymphocytes. (12 Dec 1998) |
| immunoglobulins, thyroid-stimulating | Autoantibodies that bind to the thyroid-stimulating hormone (tsh) receptor (receptors, thyrotropin) on thyroid epithelial cells. The autoantibodies mimic tsh causing an unregulated production of thyroid hormones characteristic of graves' disease. (12 Dec 1998) |
| immunohematology | That division of haematology concerned with immune, or antigen-antibody reactions and with related changes in the blood. (05 Mar 2000) |
| immunohistochemistry | Histochemical localization of immunoreactive substances using labelled antibodies as reagents. (12 Dec 1998) |
| immunolocalization | Refers to use of immunological techniques, including specific antibody, to identify the location of molecules or structures within cells or tissues. (05 Mar 2000) |
| immunologic | <immunology> Pertaining to immunology. (18 Nov 1997) |
| immunologic and biological factors | A collective grouping for biologically active substances that play a role in the functioning of the immune system and those that show biological or physiological activity. (12 Dec 1998) |
| immunologic capping | The process by which lymphoid cell surface immunoglobulin receptors, when exposed to bivalent anti-ig antibodies, collect in patches and form a cap at one pole of the cell. The caps may then be endocytosed or shed into the environment in the form of antigen-antibody complexes. Capping has also been induced by lectins and antigens. (12 Dec 1998) |
| immunologic deficiency syndromes | Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral. (12 Dec 1998) |
| immunologic diseases | Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated or both. (12 Dec 1998) |
| immunologic factors | Biologically active substances whose activities affect or play a role in the functioning of the immune system. (12 Dec 1998) |
| immunologic high dose tolerance | Induction of tolerance by exposure to large amounts of protein antigens. (05 Mar 2000) |