| dystrophia adiposogenitalis | A disorder characterised primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys; dwarfism is rare, and when present is thought to reflect hypothyroidism. Visual loss, behavioural abnormalities, and diabetes insipidus may occur. Frohlich's syndrome often is used synonymously for this disorder, although the original case involved a pituitary tumour; most cases are thought to result from hypothalamic dysfunction in areas regulating appetite and gonadal development. The most common causes are pituitary and hypothalamic neoplasms. Synonym: adiposis orchica, adiposogenital degeneration, adiposogenital dystrophy, adiposogenital syndrome, hypophysial syndrome, hypothalamic obesity with hypogonadism. Origin: L. Fr. G. Dys-, bad, + trophe, nourishment (05 Mar 2000) |
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| dystrophia brevicollis | A condition marked by symptoms of dystrophia adiposogenitalis together with a deforming shortness of the neck, but without synostosis of the cervical vertebrae seen in Klippel-Feil syndrome. (05 Mar 2000) |
| dystrophia myotonica | <neurology> An inherited human neuromuscular disease classed as an autosomal dominant disease in which there is progressive muscle weakening and wasting. A triplet repeat syndromes (like fragile X syndrome), this most common adult form of muscular dystrophy is caused by expansion of the unstable trinucleotide repeat CTG in the 3' untranslated region on chromosome 19q13 (cAMP-dependent muscle protein kinase gene). Anticipation has been associated with further expansion of the repeat upon transmission to subsequent generations (the inheritance pattern is autosomal dominant), although contraction has been noted to occur as well. Especially severe neonatal cases have been born to affected mothers preferentially, suggesting a role for genomic imprinting as well. The classic physical signs include atrophy of facial muscles, cataracts, and delayed muscle relaxation. Detection of the expanded trinucleotide repeat is accomplished by PCR or Southern blot and expansion appears to correlate with decreased transcription of the protein kinase gene. Inheritance: autosomal dominant. (29 Dec 1997) |
| dystrophia unguium | Dystrophy of the nails. (05 Mar 2000) |
| dystrophia ungulae | A condition of the hoof wall in the toe region of horses, characterised by loss of substance and change in character of the horn, most often as a sequela of mild chronic laminitis. Synonym: dystrophia ungulae, hollow wall. (05 Mar 2000) |
| dystrophic | Relating to dystrophy. (05 Mar 2000) |
| dystrophic calcification | Calcification occurring in degenerated or necrotic tissue, as in hyalinised scars, degenerated foci in leiomyomas, and caseous nodules. (05 Mar 2000) |
| dystrophic calcinosis | A deposit of calcium in the skin; usually occurs secondary to a preexisting inflammatory, degenerative, or neoplastic dermatosis, and is frequently seen in scleroderma. Synonym: dystrophic calcinosis, skin stones. (05 Mar 2000) |
| dystrophin | <protein> Protein (400 kD) from skeletal muscle that is missing in Duchenne muscular dystrophy. Its exact role is not yet clear, though it seems to be associated with the cytoplasmic face of the sarcolemma and T tubules and may form part of the membrane cytoskeleton. There are sequence homologies with nonmuscle _ actinin and with spectrin. (18 Nov 1997) |
| dystrophy | <pathology> Any disorder arising from defective or faulty nutrition, especially the muscular dystrophies. Origin: L. Dystrophia, Gr. Trephein = to nourish (18 Nov 1997) |
| dystrophy, myotonic | Inherited disease with myotonia (irritability and prolonged contraction of muscles), mask-like face, premature balding, cataracts, and cardiac disease. Due to a trinucleotide repeat (a stuttering sequence of three bases) in the DNA. (12 Dec 1998) |
| dystropy | Abnormal or eccentric behaviour. Origin: dys-+ G. Tropos, a turning (05 Mar 2000) |
| dysuria | <symptom> Painful or difficult urination. Origin: Gr. Ouron = urine (18 Nov 1997) |
| dysuric | Relating to or suffering from dysuria. (05 Mar 2000) |
| dysury | <medicine> Difficult or painful discharge of urine. Origin: L. Dysuria, Gr.; + urine: cf. F. Dysurie. Source: Websters Dictionary (01 Mar 1998) |
| dysuria |
Difficult or painful urination.
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| dystrophic |
Disorder caused by incorrect nutrition.
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| dysplasia |
An abnormal tissue development, common in the bones of the canine.
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| dysecdysis |
Abnormal shedding of the skin in reptiles.
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| dyspepsia |
Digestive upset, which can include nausea, vomiting, and heartburn.
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