| cholesterosis cutis | <dermatology, pathology> An accumulation of an excess of lipids in the body due to disturbance of lipid metabolism and marked by the formation of foam cells in skin lesions. (16 Dec 1997) |
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| cholesteryl ester synthetase | <enzyme> Independent of coenzyme a; dependent on bile salts Registry number: EC 2.3.1.- (26 Jun 1999) |
| cholestyramine | <chemical> Strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium as cl(-) anion. It exchanges chloride ions with bile salts, thus decreasing their concentration and that of cholesterol. It is used as a hypocholesteraemic in diarrhoea and biliary obstruction and as an antipruritic. Pharmacological action: anion exchange resins, anticholesteraemic agents, antipruritics. Chemical name: Cholestyramine (12 Dec 1998) |
| cholestyramine resin | A strongly basic anion-exchange resin in the chloride form, consisting of a copolymer of styrene and divinylbenzene with quaternary ammonium functional groups; it lowers the blood cholesterol by binding the bile acids in the intestine, thus promoting their excretion in the faeces instead of reabsorption from the bowel; used in the treatment of hypercholesterolaemia, xanthomatous biliary cirrhosis, and other forms of xanthomatosis. (05 Mar 2000) |
| choleuria | The presence of various bile salts, or bile, in the urine. Synonym: choleuria, choluria. Origin: bili-+ G. Ouron, urine (05 Mar 2000) |
| choleverdin | <biochemistry> A green pigment found in bile which is formed during haem catabolism, mainly the breaking down of old red blood cells, within the liver. It has the chemical formula C33H34N4O6. It transforms into the red-orange bile pigment bilirubin. (09 Oct 1997) |
| cholic | Relating to the bile. Synonym: choleic. (05 Mar 2000) |
| cholic acid | A family of steroids comprising the bile acids (or salts), generally in conjugated form (e.g., glycocholic and taurocholic acids). Chemically, cholic acids are cholan-24-oic (cholanic) acids (the terminal C24 of cholane becoming a -COOH group); biologically, cholic acids are derived from cholesterol (a cholestane derivative) and display varying degrees of oxidation (OH groups) and orientation at positions 3, 7, and 12. It is these oxidations and orientations that distinguish the several cholic acid; e.g., cholic acid is 3a,7a,12a-trihydroxy-5b-cholan-24-oic acid, deoxycholic acid is 3a,12a-dihydroxy-5b-cholanic acid. Synonym: cholalic acid, cholanic acid. (05 Mar 2000) |
| cholic acids | <chemical> The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilise fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics. Pharmacological action: cholagogues and choleretics, gastrointestinal agents. (12 Dec 1998) |
| cholicele | Enlargement of the gallbladder due to retained fluids. Origin: G. Chole, bile, + kele, tumour (05 Mar 2000) |
| choline | <biochemistry> Esterified in the head group of phospholipids (phosphatidylcholine and sphingomyelin) and in the neurotransmitter acetylcholine. Otherwise a biological source of methyl groups. (18 Nov 1997) |
| choline acetylase | <enzyme> An enzyme that controls the production of acetylcholine, appears to be depleted in the brains of alzheimer patients. (22 May 1997) |
| choline acetyltransferase | <enzyme> An enzyme that controls the production of acetylcholine, appears to be depleted in the brains of alzheimer patients. (22 May 1997) |
| choline chloride | <chemical> A lipotropic agent. (05 Mar 2000) |
| choline deficiency | A condition produced by a deficiency of choline in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the b vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (12 Dec 1998) |