| LSANA | leukocyte-specific antinuclear antibody |
|---|---|
| MCSPG | melanoma-specific chondroitin sulfate proteoglycan |
| mel-CSPG | melanoma-specific chondroitin sulfate proteoglycan |
| MMPI | matrix metalloproteinase specific for collagen type I; Minnesota Multiphasic Personality Inventory |
| MSBC | maximum specific binding capacity |
| T antigen | <molecular biology> Proteins coded by viral genes that are expressed early in the replication cycle of papovaviruses such as SV40 and polyoma. Essential for normal viral replication, they are also expressed in nonpermissive cells transformed by these viruses. Originally detected as Tumour antigens by immunofluorescence with antisera from tumour bearing animals. SV40 has two, large T and small t, polyoma has three, large, middle and small. Appear to be collectively responsible for transformation by these viruses. (14 Oct 1997) |
|---|---|
| T-cell antigen receptors | Receptors present on T-cells that interact with both processed antigen and major histocompatibility antigens simultaneously. (05 Mar 2000) |
| T-dependent antigen | An antigen that requires T helper cells in addition to appropriate B-cells. Most antigens are T-dependent. (05 Mar 2000) |
| theta antigen | A surface glycoprotein that is present on thymocytes of mice and rats. (05 Mar 2000) |
| thymus-independent antigen | An antigen that does not require T helper cell activation in order for the host's B-cells to be stimulated. Repeating polymers such as polysaccharides are examples of T-independent antigens. (05 Mar 2000) |
| tissue polypeptide antigen | Serological tumour marker composed of a molecular complex of cytokeratins 8, 18, and 19. It is used in the diagnosis and staging of bronchogenic carcinoma. (12 Dec 1998) |
| TL antigen | <immunology> The mouse antigens coded for by the TLa complex, in normal animals only found on intrathymic lymphocytes, but also seen on leukaemic cells (hence, thymus leukaemia antigen) in certain forms of the disease in mice. The molecules have structures similar in some ways to Class I MHC products but are disulphide bonded tetramers of two 45 kD chains and two 12 kD chains of _2 microglobulin type. (18 Nov 1997) |
| transplantation antigen | <immunology> Any antigen that is antigenically active in graft rejection. In practice the major histocompatibility complex and the H Y antigens and to a lesser extent minor histocompatibility antigens. (18 Nov 1997) |
| Epithelial membrane antigen | <cell biology> Heavily glycosylated membrane glycoprotein. Encoded by the MUC 1 gene, has a molecular weight of around 300 kD, more than half of which is O linked glycan. There is a 69 residue cytoplasmic domain and the extracellular domain may extend hundreds of nanometres beyond the plasma membrane, the increased expression in carcinoma cells may reduce the adhesion and mask antigenic properties of the cells. Similar functions are ascribed to ASGP, epiglycanin and leucosialin. (18 Nov 1997) |
| Js antigen | sutter Blood Group |
| K antigen | Capsular antigens of bacteria usually polysaccharide. (18 Nov 1997) |
| Fas antigen | <protein> Cell surface transmembrane protein (35 kD) that mediates apoptosis. Has structural homology with TNF receptor and NGF receptor. May play a part in negative selection of autoreactive T-cells in the thymus. (18 Nov 1997) |
| ki-67 antigen | A cell cycle and tumour growth marker which can be readily detected using immunocytochemistry methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells. (12 Dec 1998) |
| Km antigen | Allotypic antigens that are present on human kappa immunoglobulin light chains. Synonym: InV group antigen. (05 Mar 2000) |
| Kveim antigen | A saline suspension of human sarcoid tissue prepared from the spleen of an individual with active sarcoidosis; used in the Kveim test. Synonym: Kveim-Stilzbach antigen. (05 Mar 2000) |