| sequential a. |
a statistical technique in which the sample size is not fixed in advance, rather, sampling is stopped as soon as significant results are observed. The criteria for stopping the trials at each sample size are set so that the overall probability (for all sample sizes) of falsely rejecting the null hypothesis at any step is held to a preset level. Cf. hypothesis test
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| sequential c. |
chemotherapy in which several agents are administered one at a time rather than concurrently, in order to to optimize dosage and increase patient tolerance.
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| sequential d. |
a polymeric antigenic determinant with antigenic specificity determined by monomer sequence rather than monomer composition.
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| sequential m. |
in an enzyme-catalyzed reaction, the binding of the enzyme by all substrates, forming a complex, prior to the release of any products; binding may occur in a fixed order or may be random. Cf. ping-pong m.
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| sequestered a.’s |
the cellular constituents of tissue (e.g., lens of the eye) sequestered anatomically from the lymphoreticular system during embryonic development and thus thought not to be recognized as “self.” Should such tissue be exposed to the lymphoreticular system during adult life, an autoimmune response would be elicited.
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