| 5-methylcytosine-DNA glycosylase | <enzyme> Binds equally well to methylated and non-methylated DNA; isolated from developing chicken embryos and mouse fibroblasts; mw 52.5 kD Registry number: EC 3.2.2.- (26 Jun 1999) |
|---|---|
| 8-hydroxy-5-deazaflavin-dependent DNA photolyase | <enzyme> From anacystis nidulans; purified in streptomyces coelicolor; distinguish from folate-dependent DNA photolyase Registry number: EC 4.1.99.- Synonym: 8-hdfd-DNA photolyase (26 Jun 1999) |
| formamidopyridine-DNA glycosylase | <enzyme> Substrate is the ring-opened form of 7-methylguanine; has been sequenced; genbank af026691 Registry number: EC 3.2.2.23 Synonym: fap-DNA glycosylase, fapy-DNA glycosylase, formamidopyrimidine-DNA glycosylase, 8-oxoguanine DNA glycosylase, 8-hydroxyguanine DNA glycosylase, 8-hydroxyguanine endonuclease, 8-oh-gua endonuclease, fpg protein, E coli, fpg gene product, E coli, mutm protein, oh8 guanine excision repair enzyme, ogg1 gene product (26 Jun 1999) |
| forms of DNA i, II and III | Refers to circular DNA removed from viruses and as plasmids. Form I is the DNA in its normal, supercoiled form. Form II is the DNA after one of the two strands has been nicked (cut apart), and is circular. Form III is the DNA after both strands have been broken, and is linear. (09 Oct 1997) |
| linker DNA | The DNA found between nucleosomes on chromatin; since it is not complexed to proteins as strongly as other forms of DNA, it is accessible to exonuclease hydrolysis. (05 Mar 2000) |
| acetoacetyl-acyl carrier protein synthase | <enzyme> E coli enzyme, that catalyses condensation of malonyl-acyl carrier protein plus acetyl-acyl carrier protein; not inhibited by cerulenin Registry number: EC 2.3.1.- Synonym: acetoacetyl-acp synthase (26 Jun 1999) |
| acid soluble spore protein | <molecular biology> A DNA binding protein in the spores of some bacteria, thought to stabilise the DNA in an A configuration, so protecting it from cleavage by enzymes or UV light. (18 Nov 1997) |
| acute-phase protein | <haematology> These plasma proteins (in addition to fibrinogen) increase 25% or more in response to inflammation and injury are under direct control of interleukin-6 (IL-6) (hepatocyte-stimulating factor). Other proteins which increase are ceruloplasmin, C3 and C4 which increase 50% or more; alpha-1 acid glycoprotein, alpha-1 antitrypsin, haptoglobin and fibrinogen (the major determinant of viscosity 1 ) which increase two- to fourfold; C-reactive protein (CRP) and serum amyloid A which increase several hundred-fold. Despite long-held clinical opinion to the contrary, available data indicate that neither ESR nor measurement of specific acute-phase reactants are useful in excluding underlying infection or inflammation regardless of the pretest probability. These proteins are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. They can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumour markers. See also: amyloid, c-reactive protein, erythrocyte sedimentation rate, viscosity. (25 Jun 1999) |
| acyl-(acyl-carrier-protein)-phospholipid acyltransferase | <enzyme> Catalyses the formation of phosphatidylethanolamine from acyl-acyl carrier protein and 2-acyl-sn-glycero-3-phosphoethanolamine Registry number: EC 2.3.1.40 Synonym: 2-acyl-gpe acyltransferase, 2-acylglycerophosphoethanolamine acyltransferase (26 Jun 1999) |
| acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine acyltransferase | <enzyme> E coli enzyme involved in lipid a biosynthesis; uses beta-hydroxymyristoyl-acyl carrier protein to form udp-3-monoacyl-n-acetylglucosamine; amino acid sequence given in second source Registry number: EC 2.3.1.129 Synonym: udp-aguatransferase, lpxa protein, udp-n-acetylglucosamine-3-acyltransferase, udp-n-acetylglucosamine 3-o-acyltransferase, udp-3-o-(r-3-hydroxymyristoyl)glucosamine-n-acyltransferase, lpxd protein, fira gene product, fira protein (26 Jun 1999) |
| acyl carrier protein | <protein> A small (77 peptides long) protein which binds six other enzymes involved in fatty acid synthesis. It was first isolated in E. Coli bacteria. (09 Oct 1997) |
| acyl carrier protein acylase | <enzyme> From E coli Registry number: EC 2.3.1.- Synonym: acp acylase (26 Jun 1999) |
| acyl protein synthetase | <enzyme> Component of the fatty acid reductase complex of luminescent bacteria Registry number: EC 2.3.1.- Synonym: luxe gene product, fatty acyl-protein synthetase (26 Jun 1999) |
| AKT1 protein kinase | <enzyme> Human homolog of v-akt oncogene product Registry number: EC 2.7.10.- Synonym: akt1 protein, human (26 Jun 1999) |
| AMP-activated protein kinase kinase | <enzyme> An endogenous kinase kinase; reactivates the inactive form of AMP-activated protein kinase (AMP-pk); phosphorylates the 63-kD subunit of AMP-pk Registry number: EC 2.7.1.- Synonym: AMP-pk reactivator, hmg CoA reductase kinase kinase (26 Jun 1999) |