| cyclic AMP receptor protein | A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. Cyclic AMP receptor protein was originally identified as a catabolite gene activator protein. It was subsequently shown to regulate several functions unrelated to catabolism, and to be both a negative and a positive regulator of transcription. Cell surface cyclic AMP receptors are not included (cyclic AMP receptors), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of cyclic AMP-dependent protein kinases. (12 Dec 1998) |
|---|---|
| cyclic GMP-dependent protein kinases | <enzyme> A group of enzymes that are dependent on cyclic GMP and catalyses the phosphorylation of serine or threonine residues of proteins. Registry number: EC 2.7.10.- (12 Dec 1998) |
| cyclic nucleotide-regulated protein kinases | <enzyme> A group of enzymes that catalyses the phosphorylation of serine or threonine residues of proteins and is dependent on cyclic nucleotides. Registry number: EC 2.7.10.- (12 Dec 1998) |
| pregnancy-associated alpha-plasma protein | An alpha 2-macroglobulin, molecular weight approximately 750,000 now believed to be a pregnancy-specific protein. Its plasma levels increase steadily during the second trimester and continue to rise until the end of gestation. (12 Dec 1998) |
| pregnancy-associated beta-plasma protein | A beta-globulin now believed to be a pregnancy-specific protein. Its plasma levels increase steadily during pregnancy until the end of gestation. (12 Dec 1998) |
| cysteine string protein | <protein> (CSPs) Peripheral membrane proteins that contain more than 10 palmitoylated cysteines and a DNA J homology domain. Nature 375:647 (18 Nov 1997) |
| SA-induced protein kinase | <enzyme> 48-kD map kinase isolated from nicotiana tabacum; genbank u94192 Registry number: EC 2.7.10.- Synonym: p48 sip kinase, salicylic acid-induced protein kinase, sipk enzyme (26 Jun 1999) |
| prion protein | Small, infectious proteinaceous particle, of non-nucleic acid composition because of its resistance to nucleases; the causative agent, either on a sporadic, genetic, or infectious basis, of six neurodegenerative diseases in animals, and four in humans; the latter include the spongiform encephalopathies of kuru, Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker syndrome and fatal familial insomnia. The gene encoding for the PrP is found on chromosome 20. Synonym: prion. (05 Mar 2000) |
| heat-shock protein | <cell biology, molecular biology, protein> Families of proteins conserved through prokaryotic and eukaryotic cells and bacteria in response to hyperthermia and other environmental stresses, although some are constitutively expressed. They increase thermal tolerance and perform functions essential to cell survival under these conditions. Some serve to stabilise proteins in abnormal configurations, play a role in folding and unfolding of proteins and the assembly of oligomeric complexes and may act as chaperonins. Hsp90 complexes with inactive steroid hormone receptor and is displaced upon ligand binding. Four major sub classes are recognised: hsp90, hsp70, hsp60 and small hsps. Hsps have been suggested to act as major immunogens in many infections. Acronym: HSP (12 Dec 1998) |
| heat-shock protein 27 kinase | <enzyme> Phosphorylates hsp 26 on serine residues when stimulated by tumour necrosis factor or interleukin 1 Registry number: EC 2.7.1.- Synonym: hsp 27 kinase, heat-shock protein 27 kinase, hsp27 kinase (26 Jun 1999) |
| helix destabilising protein | <molecular biology, protein> Proteins involved in DNA replication. They bind cooperatively to single stranded areas of a DNA molecule in a double helix, causing the helix to unwind and preventing the reformation of the duplex and extending the DNA backbone, thus making the exposed bases more accessible for base pairing. (10 Oct 1997) |
| protective protein | An immunoglobulin molecule that has a specific amino acid sequence by virtue of which it interacts only with the antigen that induced its synthesis in cells of the lymphoid series (especially plasma cells) or with antigen closely related to it. Antibodies are classified according to their ode of action as agglutinins, bacteriolysins, haemolysins, opsonins, precipitins, etc. (18 Nov 1997) |
| protein | <biochemistry> Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen and usually sulphur, the characteristic element being nitrogen and which are widely distributed in plants and animals. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins and each protein has a unique, genetically defined amino acid sequence which determines its specific shape and function. They serve as enzymes, structural elements, hormones, immunoglobulins, etc. And are involved in oxygen transport, muscle contraction, electron transport and other activities throughout the body and in photosynthesis. Origin: Gr. Protos = first (18 Nov 1997) |
| protein 4.1 | A peripheral protein that binds tightly to spectrin in the red cell membrane; it also binds to certain glycophorins and helps determine the shape and flexibility of the red blood cell. (05 Mar 2000) |
| SCH9 protein kinase | <enzyme> Acts independently of camp-dependent protein kinase and the transcriptional activator adr1 in controlling yeast adh2 expression Registry number: EC 2.7.1.- (26 Jun 1999) |