| immunoglobulin M | <immunology> An immunoglobulin M molecule (970 kD) is built up from five immunoglobulin G type monomers joined together, with the assistance of J chains, to form a cyclic pentamer. Immunoglobulin M binds complement and a single molecule bound to a cell surface can lyse that cell. Immunoglobulin M is usually produced first in an immune response before immunoglobulin G. The human red cell isoantibodies are immunoglobulin M antibodies. Heavy chain (mu chain) is rather larger than the heavy chains of other immunoglobulins. (30 Mar 1998) |
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| immunoglobulin superfamily | <immunology> A large group of proteins with immunoglobulin like domains. most are involved with cell surface recognition events. Sequence homologyy suggests that immunoglobulins, MHC molecules, some cell adhesion molecules and cytokines receptors share close homology and thus belong to a multigene family. (30 Mar 1998) |
| immunoglobulin switch region | Site on a segment of a B-cell immunoglobulin heavy-chain gene where recombination or rearrangement can occur, expressed as isotype or allotype switching, maturation of immune response, or recombination of DNA molecules. It is found on genes encoding all five immunoglobulin heavy chains. (12 Dec 1998) |
| immunoglobulin variable region | That region of the immunoglobulin (antibody) molecule that varies in its amino acid sequence and composition, confers the antigenic specificity, and is thought to comprise the binding site for the antigen. It is located at the n-terminus of the fab fragment of the immunoglobulin. It includes hypervariable and framework regions, vh family subgroups, and the complementarity-determining region. (12 Dec 1998) |
| immunoglobulins | Any of the structurally related glycoproteins that function as antibodies. They are divided into five classes (IgA, IgD, IgE, IgG, IgM) on the basis of structure and biological activity. (12 Dec 1998) |
| immunoglobulins, alpha-chain | Heavy chains found in the fab and fc fragments of IgA and having a molecular weight of approximately 58 kD. They contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to the fc fragment. (12 Dec 1998) |
| immunoglobulins, delta-chain | Heavy chains found in the fab and fc fragments of IgD and having a molecular weight of approximately 64 kD. They contain about 500 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the fc fragment. (12 Dec 1998) |
| immunoglobulins, epsilon-chain | Heavy chains found in the fab and fc fragments of IgE and having a molecular weight of approximately 72 kD. They contain about 550 amino acid residues arranged in five domains and about three times more carbohydrate than the heavy chains of IgA, IgD, and IgG. (12 Dec 1998) |
| immunoglobulins, fab | Antigen-binding fragments composed of one entire light chain and about half of one of the heavy chains, linked to each other by disulfide bonds. Fab contains the antigen binding site which is part of the variable region of the immunoglobulin molecule. (12 Dec 1998) |
| immunoglobulins, fc | Crystallizable fragments composed of the carboxy-terminal halves of both heavy chains linked to each other by disulfide bonds. Fc fragments are responsible for the effector functions of antibodies (complement fixation, binding to cell membranes, and placental transport). (12 Dec 1998) |
| immunoglobulins, gamma-chain | Heavy chains found in the fab and fc fragments of IgG and having a molecular weight of approximately 51 kD. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the fc fragment. The gamma chains of the four IgG subgroups are not identical, but resemble each other more closely than the heavy chains of a different immunoglobulin. (12 Dec 1998) |
| immunoglobulins, heavy-chain | Major components of immunoglobulin molecules. They are the larger of the two types of polypeptide chains responsible for the biological and immunological properties of the different immunoglobulins. They differ according to the class of ig from which they were isolated, contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kD. One ig molecule comprises two heavy and two light chains. (12 Dec 1998) |
| immunoglobulins, intravenous | Immunoglobulin preparations used in intravenous infusion, containing primarily IgG. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including paediatric aids, primary hypergammaglobulinaemia, scid, cytomegalovirus infections in transplant recipients, chronic lymphocytic leukaemia, kawasaki syndrome, infection in neonates, and idiopathic thrombocytopenic purpura. (12 Dec 1998) |
| immunoglobulins, j-chain | The immunoglobulin fragments found in the light chain fractions of secretory IgA and polymeric IgM in a ratio of one j chain per one IgA dimer or one IgM pentamer. It is a polypeptide with a molecular weight of about 17 kD and probably serves either to bind the components of the globulins together or to transfer the globulins across membranes. (12 Dec 1998) |
| immunoglobulins, kappa-chain | One of the light chains of the immunoglobulins with a molecular weight of approximately 22 kD. They constitute about 60% of all light chains and can be recognised serologically as well as by their specific amino acid sequence. (12 Dec 1998) |
Synonyms : Immunoglobulin
Synonyms : Alphaglobin, Endobulin, Gamimmune, Gamimmune N, Gamimune, Gamimune N, Gammagard, Gammonativ, Globulin-N, IV Immunoglobulins, Immune Globulin, Intravenous, Intraglobin, Intraglobin F, Intravenous IG, Iveegam, Modified Immune Globulin (Anti-Echovirus Antibody)
Synonyms : Immunoglobulin, Thyroid-Stimulating, Thyroid Stimulating Antibody, Thyroid-Stimulating Immunoglobulin, Antibody, Thyroid Stimulating, Immunoglobulin, Thyroid Stimulating, Stimulating Antibody, Thyroid, Thyroid Stimulating Antibodies
Synonyms : Immunogold Technics, Immunogold-Silver Technics, Immunolabeling Technics, Immunogold Silver Technics, Immunogold Silver Techniques, Immunogold Technic, Immunogold Technique, Immunogold-Silver Technic, Immunogold-Silver Technique, Immunolabeling Technic
Synonyms : Immunological Capping, Capping, Immunological
| immunosuppression |
Suppression of the body's immune system and its ability to fight infections or disease. Immunosuppression may be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation to prevent rejection of the donor tissue. It may also result from certain diseases such as AIDS or lymphoma or from anticancer drugs.
출처: www.stjude.org/glossary
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| immunization |
A technique used to cause an immune response that results in resistance to a specific disease, especially an infectious disease.
출처: www.stjude.org/glossary
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| immunoassay |
A test that uses the binding of antibodies to antigens to identify and measure certain substances. Immunoassays may be used to diagnose disease. Also, test results can provide information about a disease that may help in planning treatment (for example, when estrogen receptors are measured in breast cancer).
출처: www.stjude.org/glossary
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| immunocompetence |
The ability to produce a normal immune response.
출처: www.stjude.org/glossary
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| immunocompromised |
Having a weakened immune system caused by certain diseases or treatments.
출처: www.stjude.org/glossary
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| IMM | identification of a substance (especially a protein) by its action as an antigen |
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| IMM | of or relating to immunochemistry |
| IMM | identification of a substance (especially a protein) by its action as an antigen |
| IMM | the field of chemistry concerned with chemical processes in immunology (such as chemical studies of antigens and antibodies) |
| IMM | immunological disorder in which some part of the body's immune system is inadequate and resistance to infectious diseases is reduced |
| IMM | electrophoresis to separate antigens and antibodies |
| IMM | (immunology) a technique that uses antibodies linked to a fluorescent dye in order to study antigens in a sample of tissue |
| IMM | any substance or organism that provokes an immune response (produces immunity) when introduced into the body |
| IMM | a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response |
| IMM | one of the most common of the five major classes of immunoglobulins |
| IMM | one of the five major classes of immunoglobulins |
| IMM | one of the five major classes of immunoglobulins |