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sickle cell–thalassemia d. any of several hereditary anemias involving simultaneous heterozygosity for hemoglobin S and a thalassemia gene; symptoms resemble those of sickle cell anemia. Called also microdrepanocytosis, microdrepanocytic d., hemoglobin S–thalassemia, sickle cell–thalassemia, and thalassemia–sickle cell d..
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sickle s. a scaler that removes tenacious supragingival or subgingival deposits; it has a sickle-like blade with flattened sides and a trapezoidal cross section.
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sicklemia sickle cell anemia.
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sickling the development of sickle cells in the blood, as in sickle cell anemia.
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sickling t. a method for demonstrating hemoglobin S and sickling in erythrocytes, particularly in the heterozygous state, by reducing the environmental oxygen around them. It may be done by simply sealing a drop of blood under a coverslip or may be speeded up by adding 2 per cent sodium metabisulfite or sodium dithionite to the preparation.
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