| protiston | Origin: NL. <zoology> One of the Protista. Source: Websters Dictionary (01 Mar 1998) |
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| protium | The common hydrogen-1 isotope, making up 99.985% of the hydrogen-1 atoms occurring in nature. Synonym: protium. (05 Mar 2000) |
| proto- | 1. <prefix> A combining form prefix signifying first, primary, primordial; as, protomartyr, the first martyr; protomorphic, primitive in form; protoplast, a primordial organism; prototype, protozoan. 2. <chemistry> Denoting the first or lowest of a series, or the one having the smallest amount of the element to the name of which it is prefixed; as protoxide, protochloride, etc. Sometimes used as equivalent to mono-, as indicating that the compound has but one atom of the element to the name of which it is prefixed. Also used adjectively. Origin: Gr. Protos first, a superl. Fr. Before. (29 Oct 1998) |
| proto-oncogene | <molecular biology> The normal, cellular equivalent of an oncogene, thus usually a gene involved in the signalling or regulation of cell growth. In general, cellular proto-oncogenes are prefixed with a c, rather than their abnormal viral counterparts, that are prefixed with a v, for example c myc and v myc. They are fragments of DNA, related to oncogenes but are the normal switches used to control growth and tissue repair. (06 Oct 1997) |
| proto-oncogene protein p21(ras) | Cellular protein encoded by the c-ras genes. The protein has GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia. (12 Dec 1998) |
| proto-oncogene protein pp60(c-src) | <enzyme> Membrane-associated tyrosine-specific kinase encoded by the c-src genes. It has an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to pp60(v-src) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase. Registry number: EC 2.7.1.- (12 Dec 1998) |
| proto-oncogene proteins | Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity. (12 Dec 1998) |
| proto-oncogene proteins c-abl | Membrane proteins encoded by the c-abl genes. They exhibit tyrosine kinase activity and play a role in normal haematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific n-terminal amino acids are deleted, releasing the kinase from negative regulation. (12 Dec 1998) |
| proto-oncogene proteins c-bcl-2 | Membrane proteins encoded by the bcl-2 genes and serving as a potent inhibitor of cell death by apoptosis. The proteins are found on mitochondrial, microsomal, and nuclear membrane sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (12 Dec 1998) |
| proto-oncogene proteins c-erbb-2 | Cellular proteins in the epidermal growth factor receptor family encoded by the c-erbb genes. These proteins are overexpressed in a significant portion of adenocarcinomas found at various sites, especially in the breast. Gene amplification appears to be the predominant method leading to overexpression. (12 Dec 1998) |
| proto-oncogene proteins c-fos | Cellular DNA-binding proteins encoded by the c-fos genes (genes, fos). They are involved in growth-related transcriptional control. C-fos combines with c-jun (proto-oncogene proteins c-jun) to form a c-fos/c-jun heterodimer (transcription factor ap-1) that binds to the tre (tpa-responsive element) in promoters of certain genes. (12 Dec 1998) |
| proto-oncogene proteins c-jun | Cellular DNA-binding proteins encoded by the c-jun genes (genes, jun). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun. (12 Dec 1998) |
| proto-oncogene proteins c-kit | Tyrosine kinase membrane receptors which are the natural ligands for mast cell growth factor (steel factor). This interaction is crucial for the development of haematopoietic, gonadal, and pigment stem cells. (12 Dec 1998) |
| proto-oncogene proteins c-met | <enzyme> A transmembrane tyrosine kinase that is the receptor for hepatocyte growth factor (scatter factor). It consists of an extracellular alpha chain which is disulfide linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and critical sites for the regulation of kinase activity. Registry number: EC 2.7.11.- (12 Dec 1998) |
| proto-oncogene proteins c-mos | Cellular proteins encoded by the c-mos genes (genes, mos). They function in the cell cycle to maintain maturation-promoting factor in the active state and have protein-serine/threonine kinase activity. Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (12 Dec 1998) |
Synonyms :
Synonyms : Chondroitin Sulfate Proteoglycan, Chondroitin Sulphate E Proteoglycan, Proteochondroitin Sulfate, Proteoglycan, Chondroitin Sulfate, Sulfate Proteoglycan, Chondroitin, Sulfate, Proteochondroitin, Sulfates, Proteochondroitin
Synonyms : Proteoglycan, Proteoglycan Type H
Synonyms :
Synonyms : Proteomes
| protofibril |
(pro
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| protoglobulose |
(pro
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| protogonocyte |
(pro
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| protoheme |
(pro
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| protohemin |
(pro
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| prot | bulge outward |
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| prot | extend out or project in space |
| prot | extending out above or beyond a surface or boundary |
| prot | capable of being thrust forward, as the tongue |
| prot | capable of being thrust forward, as the tongue |
| prot | the act of projecting out from something |
| prot | something that bulges out or is protuberant or projects from a form |
| prot | thrusting outward |
| prot | something that bulges out or is protuberant or projects from a form |
| prot | the condition of being protuberant |
| prot | curving outward |
| prot | form a rounded prominence |