| PAG | periaqueductal gray [matter]; polyacrylamide gel; pregnancy-associated globulin; proliferation-assoc... |
|---|---|
| PAGA | proliferation-associated gene A |
| PHOX | paired mesoderm homeobox [gene] |
| PMX | paired mesoderm homeobox [gene] |
| RAG | ragweed; recombination activating gene |
| therapy, gene | Insertion of normal DNA directly into cells to correct a genetic defect. Gene therapy is the treatment of disease by replacing, altering, or supplementing a gene responsible for the disease. In gene therapy for cancer, for example, researchers are trying to bolster the body's natural capacity to combat cancer and make the tumour more sensitive to other kinds of therapy. Gene therapy, still in its early stages, holds great promise for the treatment of many diseases. (12 Dec 1998) |
|---|---|
| early gene | <genetics, molecular biology> Genes that are expressed soon after viral infection of a host cell. (18 Nov 1997) |
| egg polarity gene | A gene whose product distribution in the egg determines the anterior posterior axis of subsequent development. Best characterised in Drosophila: See: bicoid, maternal effect gene. (18 Nov 1997) |
| transforming gene | <molecular biology> Genes, originally of tumour viruses, responsible for their ability to transform cells. The term now serves as an operational definition of oncogenes. (18 Nov 1997) |
| env gene | <molecular biology> One of three retrovirus genes which codes for the env glycoproteins. (09 Oct 1997) |
| epistatic gene | A gene which suppresses another gene when the two are not alternate alleles. (09 Oct 1997) |
| essential gene | <genetics> Any gene that, if it does not workcorrectly, kills the organism. (09 Oct 1997) |
| european molecular biology lab gene bank | <molecular biology> A large database of DNA sequence data in Heidelberg, Germany, compiled from international sources. It is the European equivalent to the Genbank DNA sequence databank in the United States of America. WWW: EMbase. (09 Oct 1997) |
| evolutionarily conserved gene | A gene that has remained essentially unchanged throughout evolution. Conservation of a gene indicates that it is unique and essential. There is not an extra copy of that gene with which evolution can tinker. And changes in the gene are likely to be lethal. (12 Dec 1998) |
| J gene | <molecular biology> Gene or genes coding for the Joining segment of polypeptide chain which links the V (variable regions) to the C (constant) regions of both Light and Heavy chains of immunoglobulins. During lymphoid development the DNA is rearranged so that the V genes are linked to the J region sequences. (18 Nov 1997) |
| jumping gene | <molecular biology> Populist term for transposon. (18 Nov 1997) |
| exonuclear gene | <molecular biology> A gene that is not located in the nucleus of the cell. Examples are the genes found in mitochondria and chloroplasts (organelles outside of the nucleus). (09 Oct 1997) |
| expressed gene | <molecular biology> The full use of the information in a gene via transcription and translation leading to production of a protein and hence the appearance of the phenotype determined by that gene. Gene expression is assumed to be controlled at various points in the sequence leading to protein synthesis and this control is thought to be the major determinant of cellular differentiation in eukaryotes. (18 Nov 1997) |
| expression, gene | A gene speaks. When a gene is expressed, the information encoded in the gene is translated into protein or RNA structures present and operating in the cell. Expressed genes include genes that are transcribed into messenger RNA (mRNA) and then translated into protein as well as those genes that are transcribed into RNA (such transfer and ribosomal RNAs) but not translated into protein. (12 Dec 1998) |
| extrachromosomal gene | A gene located outside of the nucleus (e.g., mitochondrial genes). (05 Mar 2000) |