| haematopoietic cell phosphatase | <enzyme> Gene found on chromosome 12p12-p13 in motheaten (me) and viable motheaten mice; shp1 is product of me gene; a single base pair change creates or alters splicing signal sequences of hc phosphatase genes with consequent abnormal mRNA splicing and expression of aberrant hc phosphatase transcript; partial aa sequence given in first source Registry number: EC 3.1.3.- Synonym: hc phosphatase, haematopoietic cell phosphatase, hcph gene product, human haematopoietic tyrosine phosphatase, heptp, leukocyte protein-tyrosine phosphatase, lc-ptp, shp1 tyrosine tyrosine phosphatase, ptp-1c, protein tyrosine phosphatase 1c (26 Jun 1999) |
|---|---|
| haematopoietic gland | A blood-forming organ, such as the spleen. (05 Mar 2000) |
| haematopoietic stem cell mobilization | The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantion. Haematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization. (12 Dec 1998) |
| haematopoietic stem cell transplantation | The transference of stem cells from one animal or human to another (allogeneic), or within the same individual (autologous). The source for the stem cells may be the bone marrow or peripheral blood. Stem cell transplantation has been used as an alternative to autologous bone marrow transplantation in the treatment of a variety of neoplasms. (12 Dec 1998) |
| haematopoietic stem cells | Progenitor cells from which all blood cells derive. (12 Dec 1998) |
| haematopoietic system | The blood-making organs; in the embryo at different ages these are the yolk sac, liver, thymus, spleen, lymph nodes, and bone marrow; after birth they are principally the bone marrow, spleen, thymus, and lymph nodes. (05 Mar 2000) |
| haematopoietin | <growth factor, hormone> Erythropoietin is a Glycoprotein (46 kD) hormone produced by specialised cells in the kidneys that regulates the production of red blood cells in the marrow. These cells are sensitive to low arterial oxygen concentration and will release erythropoietin when oxygen is low. Erythropoietin stimulates the bone marrow to produce more red blood cells (to increase the oxygen caring capacity of the blood). The measurement of this hormone in the bloodstream can indicate bone marrow disorders or kidney disease. Normal levels of erythropoietin are 0 to 19 mU/ml (milliunits per millilitre). Elevated levels can be seen in polycythaemia rubra vera. Lower than normal values are seen in chronic renal failure.Recombinant erythopoeitin is now being used therapeutically in patients. Acronym: EPO (27 Sep 1997) |
| haematoporphyria | An obsolete term for any disorder of porphyrin metabolism, regardless of the cause. Origin: haemato-+ G. Porphyra, purple (05 Mar 2000) |
| haematoporphyrin | <protein> A type of artificial porphyrin which forms when sulphuric acid is added to haemoglobin in vitro. It has the chemical formula of C34H38N4O6 and is not found naturally. (09 Oct 1997) |
| haematoporphyrin derivative | <chemical> A complex mixture of monomeric and aggregated porphyrins used in the photodynamic therapy of tumours (haematoporphyrin photoradiation). A purified component of this mixture is known as dihematoporphyrin ether. Pharmacological action: antineoplastic agent, photosensitizing agents. Chemical name: Haematoporphyrin D (12 Dec 1998) |
| haematoporphyrin photoradiation | Photochemotherapy using visible light, usually red, topically or delivered locally by fibreoptic probe to tissues sensitised with haematoporphyrins. (12 Dec 1998) |
| haematoporphyrinaemia | Older term used to designate the occurrence of haematoporphyrin in the circulating blood. (05 Mar 2000) |
| haematoporphyrins | Iron-free derivatives of haem with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. (12 Dec 1998) |
| haematoporphyrinuria | Older term used to designate enhanced urinary excretion of porphyrins. (05 Mar 2000) |
| haematopsia | Synonym: haemophthalmia. Origin: haemato-+ G. Opsis, vision (05 Mar 2000) |