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complementary genes Nonallelic, independent genes, neither of which will express its effect without the presence of the other.
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complement c.’s see complement.
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complement control p. any of a superfamily of proteins involved in complement regulation, encoded in a closely linked gene cluster, and having one or more stretches of a common short consensus repeat encoding a 60 amino acid domain. Included are factor H, C4 binding protein, decay accelerating factor, membrane cofactor protein, and several complement receptors. Called also regulator of complement activation.
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complement d. inhibition of complement fixation or complement-mediated immune hemolysis in the presence of excess antibody. Called also Neisser-Wechsberg phenomenon.
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complement f. the consumption of complement upon reaction with immune complexes containing complement-fixing antibodies, the basis of complement fixation tests, widely used procedures for the detection of antigens or antibodies. These are two-stage procedures in which heat-inactivated antiserum (or antigen) is reacted with the test material in the presence of a known amount of complement. If the homologous antigen (or antibody) is present in the test material, complement is fixed. Then sheep red blood cells and antisheep erythrocyte antibody are added; lack of hemolysis indicates complement fixation, i.e., a positive test result. Quantitative results are obtained by determining the highest dilution of antiserum or test material that gives a positive reaction. Called also Bordet-Gengou phenomenon or reaction.
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