| SCO | a large zodiacal constellation between Libra and Sagittarius |
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| SCO | (astrology) a person who is born while the sun is in Scorpio |
| SCO | the eighth sign of the zodiac |
| SCO | a cyme with flowers or branches alternating in opposite ranks |
| SCO | arachnid of warm dry regions having a long segmented tail ending in a venomous sting |
| SCO | the eighth sign of the zodiac |
| SCO | (astrology) a person who is born while the sun is in Scorpio |
| SCO | marine fishes having a tapering body with an armored head and venomous spines |
| SCO | any of various mecopterous insects of the family Panorpidae of the northern hemisphere having a long beak and long antennae |
| SCO | any of numerous tropical marine snails that as adults have the outer lip of the aperture produced into a series of long curved spines |
| SCO | any plant of the genus Phacelia |
| SCO | marine fishes having a tapering body with an armored head and venomous spines |