| neoplasms, multiple primary | Two or more abnormal growths of tissue occurring simultaneously. The neoplasms are histologically different and may be found in the same or different sites. (12 Dec 1998) |
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| drug resistance, multiple | Simultaneous resistance to a broad spectrum of structurally and functionally distinct drugs following exposure to a single agent. It is thought to result from the overexpression of genes encoding an integral plasma membrane protein, p-glycoprotein. (12 Dec 1998) |
| exostoses, multiple hereditary | Hereditary disorder transmitted by an autosomal dominant gene and characterised by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation. (12 Dec 1998) |
| familial multiple endocrine adenomatosis | The presence of functioning tumours in more than one endocrine gland, commonly the pancreatic islets and parathyroid glands, which may be associated with Zollinger-Ellison syndrome; dominant inheritance. Synonym: multiple endocrine adenomatosis. (05 Mar 2000) |
| law of multiple proportions | The relative weights in which two substances form a chemical union singly with a third are the same as, or simple multiples of, those in which they unite with each other; a corollary of the law of definite proportions. Synonym: law of multiple proportions. (05 Mar 2000) |
| lipomatosis, multiple symmetrical | Multiple circumscribed or encapsulated lipomas which may be distributed symmetrically or haphazardly or which may form a collar around the neck. (12 Dec 1998) |