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cytotoxic cell Cells of the immune system that inhibit or help to terminate an immune response, e.g., suppressor macrophages and suppressor T-cells.
Synonym: cytotoxic cell.
(05 Mar 2000)
cytotoxic drugs <pharmacology> Anti-cancer drugs which act by killing or preventing the division of cells.
See: chemotherapy.
(13 Nov 1997)
cytotoxic reaction An immunologic (allergic) reaction in which noncytotropic IgG or IgM antibody combines with specific antigen on cell surfaces; the resulting complex initiates the activation of complement which causes cell lysis or other damage, or which, in the absence of complement, may lead to phagocytosis or may enhance T lymphocyte involvement.
(05 Mar 2000)
cytotoxic T lymphocyte-specific serine protease <enzyme> Structural sequence given in first source
Registry number: EC 3.4.21.-
Synonym: cytotoxic t lymphocyte-specific serine protease ccp I, cytotoxic t lymphocyte specific serine protease ccp II, mast cell protease type II
(26 Jun 1999)
cytotoxic T-cell <haematology, immunology> Subset of T lymphocytes (mostly CD8) responsible for lysing target cells and for killing virus infected cells (in the context of Class I histocompatibility antigens).
(18 Nov 1997)
cytotoxic t-lymphocyte A type of CD8 or, less often, CD4 lymphocyte that kills diseased cells infected by a specific virus or other intracellular microbe. CTLs interact with MHC class I receptors (see Major Histocompatibility Complex). On infected cells and have the prime role in cellmediated immunity (see). Cytovene:
See: Ganciclovir.
(09 Oct 1997)
cytotoxicity The quality or state of being cytotoxic.
Antibody-dependent cell-mediated cytotoxicity (ADCC), a form of lymphocyte-mediated cytotoxicity that functions only if antibodies are bound to the target cell.
Lymphocyte-mediated cytotoxicity, the toxic or lytic activity of T-lymphocytes, which may or may not be mediated by antibodies. Cytotoxic T lymphocytes may cause lysis of cells by production of cytolytic proteins such as perforin. B-cells may cause lysis of cells by antibody-complement binding to a target cell. Natural killer cells are cytotoxic without prior sensitization. Toxicity by lymphocytes may also be mediated by antibodies; there are three kinds of cytotoxic T-lymphocytes: those that are antigen-specific as a result of previous allergization (immunization), killer cells, and natural killer cells.
See: antibody-dependent cell-mediated cytotoxicity.
(05 Mar 2000)
cytotoxicity tests, immunologic The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitised lymphocyte, an antibody, or complement.
(12 Dec 1998)
cytotoxicity, immunologic The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitised T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
(12 Dec 1998)
cytotoxin <pharmacology> Any substance that poisons living cells.
(09 Oct 1997)
cytotoxins Substances elaborated by microorganisms, plants or animals that are specifically toxic to individual cells; they may be involved in immunity or may be contained in venoms.
(12 Dec 1998)
cytotrophoblast The inner layer of the trophoblast.
Synonym: Langhans' layer.
(05 Mar 2000)
cytotrophoblastic cells Stem cell's that fuse to form the overlying syncytiotrophoblast of placental villi.
Synonym: Langhans' cells.
(05 Mar 2000)
cytotrophoblastic shell The external layer of foetally derived trophoblastic cells on the maternal surface of the placenta.
(05 Mar 2000)
cytotropic Having an affinity for cells.
Synonym: cytophilic.
(05 Mar 2000)
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cytosine One of the four ringed, nitrogen-containing bases that make up RNA and DNA.
Ãâó: www.amfar.org/cgi-bin/iowa/bridge.html
cytotoxic An agent or process that is toxic to cells (ie, suppresses cell function or causes cell death).
Ãâó: www.amfar.org/cgi-bin/iowa/bridge.html
cytoplasmic inheritance The inheritance of characters determined by genes not located on the nuclear chromosomes but on mitochondrial or chloroplast chromosomes. Such genes show inheritance patterns distinctively different from those of nuclear genes.
Ãâó: www.modernhumanorigins.com/n.html
cytoplasm The material between the nuclear and cell membranes; includes fluid (cytosol) organelles, and various membranes.
Ãâó: helios.bto.ed.ac.uk/bto/glossary/c2.htm
cytosol The fluid portion of the cytoplasm, outside the organelles.
Ãâó: helios.bto.ed.ac.uk/bto/glossary/c2.htm
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