| intraductal carcinoma | <tumour> A form of carcinoma derived from the epithelial lining of ducts, especially in the breast, where most carcinoma's arise from ductal epithelium; the neoplastic cells proliferate in irregular papillary projections or masses, filling the lumens, that are solid, cribriform, or centrally necrotic; intraductal carcinoma is a form of carcinoma in situ as it is contained by the ductal basement membrane; when it invades surrounding stroma or metastasizes it is referred to as ductal carcinoma. (05 Mar 2000) |
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| intraepidermal carcinoma | <tumour> Carcinoma in situ of the skin; e.g., Bowen's disease. (05 Mar 2000) |
| intraepithelial carcinoma | Cancer that involves only the cells in which it began and has not spread to other tissues. Lobular carcinoma in situ is found in the lobules of the breast. Ductal carcinoma in situ (also called intraductal carcinoma) arises in the ducts. (16 Dec 1997) |
| invasive carcinoma | <tumour> A neoplasm in which collections of epithelial cells infiltrate or destroy the surrounding tissue. (05 Mar 2000) |
| occult carcinoma | <tumour> A small carcinoma, either asymptomatic or giving rise to metastases without symptoms due to the primary carcinoma. (05 Mar 2000) |
| oesophageal carcinoma | <radiology> EtOH, tobacco, achalasia, Plummer-Vinson syndrome, stricture (caustic, radiation), Barrett mucosa (GE reflux, hiatus hernia), tylosis, geographical areas: Iran, China, southern France, Japan, head/neck carcinoma <strong>not</strong> Sprue / coeliac disease (12 Dec 1998) |
| oesophageal carcinoma risk factors | <radiology> P Plummer-Vinson Web, A achalasia, alcohol, B Barrett oesophagus, S stricture, T tylosis, tobacco see: oesophageal carcinoma (12 Dec 1998) |
| oesophageal carcinoma: types | <radiology> Histologic types: squamous cell carcinoma (95%), adenocarcinoma (4%), 70% from Barrett oesophagus, carcinosarcoma = pseudosarcoma = spindle cell squamous cell carcinoma, usually middle 1/3 of oesophagus, large, polypoid, smooth, intramural mass; may be pedunculated, mucoepidermoid carcinoma, adenoid cystic carcinoma radiologic types: polypoid/fungating form (most common), sessile/pedunculated tumour with lobulated surface, applecore lesion, ulcerating form, infiltrating form, gradual narrowing with smooth transition (Differential diagnosis: benign stricture), varicoid form: superficial spreading carcinoma, thickened nodular tortuous longitudinal folds (Differential diagnosis: varices) (12 Dec 1998) |
| oncoplastic carcinoma | <tumour> Obsolete term for an undifferentiated carcinoma showing no evidence by light microscopy of origin from a specific epithelial tissue, e.g., squamous or glandular epithelium. (05 Mar 2000) |
| thyroid carcinoma | <radiology> Papillary-follicular (75%), well-differentiated, 95% 5-yr survival with treatment, papillary may lead to neck nodes, follicular may lead to lungs, bone (haematogenous), anaplastic (20%), older patients, prognosis poor, medullary (5%), C cells, associated with pheochromocytoma (MEN-2 and MEN-3) see also: hot and cold nodules on radionuclide studies, risk factors (12 Dec 1998) |
| thyroid carcinoma risk factors | <radiology> Increased risk of malignancy: young female, male, history of radiation to head or neck, hard lesion, other neck masses, no shrinkage on TSH, family hx of thyroid carcinoma see: thyroid carcinoma (12 Dec 1998) |
| embryonal carcinoma | <tumour> A malignant neoplasm of the testis, composed of large anaplastic cells with indistinct cellular borders, amphophilic cytoplasm, and ovoid, round, or bean-shaped nuclei that may have multiple large nucleoli; in some instances, the neoplastic cells may form tubular structures; embryonal carcinoma's may be malignant teratomas without differentiated elements. (05 Mar 2000) |
| trabecular carcinoma | A rare malignant cutaneous tumour seen in sun-exposed skin of elderly patients composed of dermal nodules of small round cells with scanty cytoplasm in a trabecular pattern; the tumour cells contain cytoplasmic dense core granules resembling neurosecretory granules seen in Merkel cells. Synonym: primary neuroendocrine carcinoma of the skin, trabecular carcinoma. (05 Mar 2000) |
| encephalomyelitis associated with carcinoma | An encephalomyelopathy as a remote effect of carcinoma, most often oat cell carcinoma of the lung; characterised by extensive nerve cell loss, which may be diffuse, but often predominates in particular portions of the central nervous system, particularly the limbic lobes, medulla, cerebellum, and gray matter of the spinal cord. Synonym: carcinomatous encephalomyelopathy, encephalomyelitis associated with carcinoma, paracarcinomatous encephalomyelopathy. (05 Mar 2000) |
| endometrial carcinoma | <oncology, tumour> A malignant cancer which arises from the cells which line the uterus. (27 Sep 1997) |