| carcinoma, lobular | A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumours in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (12 Dec 1998) |
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| carcinoma, medullary | A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (12 Dec 1998) |
| carcinoma, mucoepidermoid | A tumour of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumours of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumour of the parotid. (12 Dec 1998) |
| carcinoma myxomatodes | An obsolete term for a form of colloid cancer in which there is myxomatous metaplasia of the cellular fibrous stroma. (05 Mar 2000) |
| carcinoma, neuroendocrine | A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumours include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, merkel cell tumour, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumours, and pheochromocytoma. Neurosecretory granules are found within the tumour cells. (12 Dec 1998) |
| carcinoma, papillary | A malignant neoplasm characterised by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (12 Dec 1998) |
| carcinoma, papillary, follicular | A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behaviour and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (12 Dec 1998) |
| carcinoma simplex | An obsolete term for any form of carcinoma in which the relative proportions of stroma and neoplastic epithelial cells are not unusual, i.e., stromal elements are not comparatively abundant, nor are they reduced in amount or lacking; an obsolete term for a carcinoma lacking any identifiable microscopic pattern, such as glandular structure. (05 Mar 2000) |
| carcinoma, skin appendage | A malignant tumour of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (12 Dec 1998) |
| carcinoma, verrucous | A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, oesophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (12 Dec 1998) |
| V-2 carcinoma | <tumour> A transplantable, highly malignant carcinoma of experimental animals that developed as a result of malignant change in a virus-induced papilloma of a domestic rabbit. (05 Mar 2000) |
| gallbladder carcinoma | <radiology> Females (80%), peak age 60 - 70 years of age, associated with, gallstones (60-90%), porcelain gall bladder (12 Dec 1998) |
| gastric carcinoma | <radiology> 3rd most common GI malignancy (after colorectal and pancreas), 95% adenocarcinoma (rarely squamous cell or adenoacanthoma), predisposing factors: pernicious anaemia (2X risk), chronic atrophic gastritis, adenomatous and villous polyp (7-27% are malignant), gastrojejunostomy types: polypoid / fungating, ulcerating / penetrating (70%), infiltrating / scirrous = linitis plastica, increase in fibrous tissue; aperistalsis; rigidity, superficial spreading carcinoma, confined to mucosa/submucosa; 95% 5-year survival, patch of nodularity; little loss of elasticity location: 60% lesser curvature, 30% GE junction, 10% greater curvature probability of malignancy of an ulcer: fundus 90%, greater curvature 70%, lesser curvature 10-15% (12 Dec 1998) |
| papillary carcinoma | <tumour> A malignant neoplasm characterised by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (05 Mar 2000) |
| verrucous carcinoma | <tumour> A well differentiated papillary squamous cell carcinoma, especially of the oral cavity or penis, that may invade locally but rarely metastasizes; the usual cytologic features of malignancy are absent. (05 Mar 2000) |