| alpha-ketoglutaramic acid | H2N-COCH2CH2COCOOH;a metabolite of glutamine formed by the action of glutamine aminotransferase; elevated in certain cases of hepatocoma. Synonym: 2-oxoglutaric acid. (05 Mar 2000) |
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| alpha-ketoglutarate | A salt or ester of alpha-ketoglutaric acid. Alpha-ketoglutarate dehydrogenase, an enzyme that catalyses the oxidative decarboxylation of 2-ketoglutaric acid to succinyldihydrolipoate; the succinyl group is later transferred to CoA and the reduced lipoate is oxidised by NAD+; a complex that is a part of the tricarboxylic acid cycle. Synonym: 2-oxoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex. (05 Mar 2000) |
| alpha-ketoglutarate dehydrogenase complex | alpha-ketoglutarate dehydrogenase |
| alpha-ketoglutarate permease | <chemical> From E coli; 432-amino acid protein; amino acid sequence given in first source Synonym: kGTP gene product, wita protein, alpha-ketoglutarate transporter (26 Jun 1999) |
| alpha-ketoisocaproate oxygenase | <enzyme> From rat liver cytosol; oxidatively decarboxylates and hydroxylates alpha-ketoisocaporate to form beta-hydroxyisovalerate; requires fe(2+) and thiol; activated by ascorbate Registry number: EC 1.13.11.- Synonym: 2-ketoisocaproate oxygenase, alpha-ketoisocaproate dioxygenase (26 Jun 1999) |
| alpha-ketosuccinamic acid | NH2-CO-CH2-CO-COOH;the transamination product of asparagine; acted upon by ω-amidase. (05 Mar 2000) |
| alpha-lactyl-thiamin pyrophosphate | An intermediate formed in the oxidative decarboxylation of pyruvate. Compare: pyruvate dehydrogenase (lipoamide). Synonym: alpha-lactyl-thiamin pyrophosphate. (05 Mar 2000) |
| alpha-l-iduronidase | <enzyme> An enzyme that hydrolyzes terminal desulfated alpha-l-iduronic acid residues of dermatan sulfate and of heparan sulfate; a deficiency of this enzyme is associated with Hurler syndrome and Scheie syndrome. (05 Mar 2000) |
| alpha-linolenic acid | <chemical> (z,z,z)-9,12,15-octadecatrienoic acid. A fatty acid that is found in plants and involved in the formation of prostaglandins. Chemical name: 9,12,15-Octadecatrienoic acid, (Z,Z,Z)- (12 Dec 1998) |
| alpha-macroglobulins | Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters. (12 Dec 1998) |
| alpha-mannosidase | <enzyme> Catalyses hydrolysis of terminal, non-reducing alpha-d-mannose residues in alpha-d-mannosides Registry number: EC 3.2.1.24 Synonym: alpha-d-mannoside mannohydrolase, alpha-d-mannosidase, neutral alpha-mannosidase, alpha mannosidase a, alpha mannosidase b, lysosomal alpha-mannosidase, laman (26 Jun 1999) |
| alpha-methylacyl-CoA racemase | <enzyme> Involved in catabolism of branched-chain fatty acids derived from isoprenoids; acts on pristanoyl-CoA and trihydroxycoprostanoyl-CoA, but not on 3-methyl branched-chain or linear-chain acyl coas; amino acid sequence has been determined; genbank u89905 (rat) and u89906 (mouse); also isolated from human liver Registry number: EC 5.1.99.- Synonym: meac CoA racemase (26 Jun 1999) |
| alpha methyl dopa | <drug> An antihypertensive drug, preferred in pregnant patients. (18 Nov 1997) |
| alpha-methyltyrosine | <chemical> An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma and decreases the frequency and severity of hypertensive attacks and related symptoms in most patients. (martindale, the extra pharmacopoeia, 30th ed) Pharmacological action: enzyme inhibitors. (12 Dec 1998) |
| alpha-msh | <chemical> A 13-amino acid peptide derived from the anterior pituitary gland in man and from the pars intermedia in lower vertebrates. Its amino acid sequence is identical to the first 13 amino acids of acth. It influences the formation of deposition of melanin in the body and produces colour changes in the skin of amphibians, fishes and reptiles. It is secreted in humans only during foetal life and occasionally during pregnancy. Chemical name: alpha-Melanotropin (pig) (12 Dec 1998) |