| adenylosuccinate synthase | <enzyme> A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyses the synthesis of adenylosuccinate from GTP, imp, and aspartate with the formation of orthophosphate and GDP. Chemical name: IMP:L-aspartate ligase (GDP-forming) Registry number: EC 6.3.4.4 (12 Dec 1998) |
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| adenylosuccinic acid | A condensation product of aspartic acid and inosine 5'-monophosphate; an intermediate in the biosynthesis of adenylic acid. Formally, it is adenylic acid with succinic acid replacing an H of the NH2 group, forming a C-N. Synonym: adenylylosuccinic acid, N-succinyladenylic acid. Acronym: sAMP (05 Mar 2000) |
| adenylpyrophosphatase | <enzyme> A group of enzymes which catalyze the hydrolysis of ATP coupled with another function such as transporting calcium across a membrane. These enzymes may be dependent on calcium, magnesium, anions, h+, or DNA. Chemical name: ATP phosphohydrolase Registry number: EC 3.6.1.3 (12 Dec 1998) |
| adenylyl | The radical of adenylic acid minus an OH from the phosphoric group; often shortened to adenyl in compound names, such as adenylosuccinic acid. (05 Mar 2000) |
| adenylyl cyclase | The former name for adenylate cyclase. (05 Mar 2000) |
| adenylyl imidodiphosphate | <chemical> 5'-adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial atpase and also inhibits ATP-dependent reactions of oxidative phosphorylation. Chemical name: 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid (12 Dec 1998) |
| adenylyl sulfate-ammonia adenylyltransferase | <enzyme> Forms adenosine 5'-phosphoramidate Registry number: EC 2.7.7.- Synonym: adenylyl sulphate-ammonia adenylyltransferase, as-aat (26 Jun 1999) |
| adenylylosuccinate lyase | <enzyme> An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyses the conversion of 5'-phosphoribosyl-4-(n-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. Chemical name: N(6)-(1,2-Dicarboxyethyl)AMP AMP-lyase Registry number: EC 4.3.2.2 (12 Dec 1998) |
| adenylylosuccinate synthase | <enzyme> A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyses the synthesis of adenylosuccinate from GTP, imp, and aspartate with the formation of orthophosphate and GDP. Chemical name: IMP:L-aspartate ligase (GDP-forming) Registry number: EC 6.3.4.4 (12 Dec 1998) |
| adenylylosuccinic acid | A condensation product of aspartic acid and inosine 5'-monophosphate; an intermediate in the biosynthesis of adenylic acid. Formally, it is adenylic acid with succinic acid replacing an H of the NH2 group, forming a C-N. Synonym: adenylylosuccinic acid, N-succinyladenylic acid. Acronym: sAMP (05 Mar 2000) |
| adenylylsulfate kinase | adenosine 5'-phosphosulfate kinase |
| adeps | 1. Denoting fat or adipose tissue. 2. The rendered fat of swine, lard, used in the preparation of ointments. Synonym: lard. See: adeps lanae. Origin: L. Lard, fat (05 Mar 2000) |
| adeps lanae | The greasy substance obtained from the wool of the sheep Ovis aries (family Bovidae). Used as an emollient base for creams and ointments. Synonym: hydrous wool fat, lanolin, wool wax. Origin: L. Fat of wool (05 Mar 2000) |
| adeps renis | An obsolete term for the layer of adipose tissue ("fatty capsule") surrounding the kidney (perirenal fat). (05 Mar 2000) |
| ADEPT | <pharmacology> A method for targeting a drug to a specific tissue, in which the targeting agent and the drug are administered separately. The drug is designed to be inactive (a prodrug) until it is converted by an enzyme, which is the targeting agent. The enzyme is coupled to an antibody that directs it to the tissue of interest. When the enzyme arrives at the tissue, the prodrug is activated only at that site, sparing other tissues from potentially toxic side effects. Acronym: ADEPT (14 Nov 1997) |