| chronic granulocytic leukaemia | <haematology> A leukaemia which is initially slowly-progressing. There are approximately 650 new cases each year in the UK. It is characterised by the presence of large numbers of abnormal mature granulocytes, circulating in the blood. Synonym: chronic granulocytic leukaemia. Acronym: CML Origin: Gr. Haima = blood (12 Jan 1998) |
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| chronic granulomatous disease | <disease> Chronic granulomatous disease is usually fatal in childhood, in which the production of hydrogen peroxide by phagocytes does not occur because of a lesion in an NADP dependent oxidase. Catalase negative bacteria are not killed and there is no luminol enhanced chemiluminescence when the cells are tested. The absence of the oxygen dependent killing mechanism is not itself fatal but seriously compromises the primary defense system. at least three separate lesions can cause the syndrome, the commonest being a defect in plasma membrane cytochrome. Acronym: CGD (12 Jan 1998) |
| chronic granulomatous disease of childhood | <radiology> Disorder of phagocytosis, two forms: X-linked recessive, autosomal recessive, usually fatal in childhood, infection by nonpathogenic organisms (catalase positive), pneumonia, osteomyelitis, diarrhoea, abdominal pain Findings: recurrent pneumonia (resolves incompletely, with abscess formation), adenopathy (big hila), hepatosplenomegaly, calcified granulomata in liver, spleen, lymph nodes, gastric antral narrowing (!) Cf: Chediak-Higashi syndrome More info: chronic granulomatous disease (12 Dec 1998) |
| chronic haemorrhagic villous synovitis | <radiology> Monoarthritis, young adults, erosions on BOTH sides of joint (!), probably inflammatory, haemosiderin deposited in synovium, articular cartilage preserved (despite extensive marginal erosions; similar to gout), NO calcification Differential diagnosis: TB (associated atrophy of muscle and bone), rheumatoid arthritis (symmetrical), synovial sarcoma (with or without calcified; outside joint), synovial osteochondromatosis (12 Dec 1998) |
| chronic hypertensive disease | The chronic accumulative effects of long-standing high blood pressure on such vital organs as the heart, kidney, and brain. (05 Mar 2000) |
| chronic hypertrophic vulvitis | Swelling of the vulval tissues due to lymphatic obstruction; in some cases it may be caused by filariasis, with induration or ulceration of the skin. Synonym: elephantiasis vulvae. (05 Mar 2000) |
| chronic hyperventilation syndrome | <syndrome> Reduced CO2 content of the blood (hypocapnia) as a result of hyperventilation of prolonged duration; may occur in anxiety states and in some chronic organic, usually cardiovascular, disease; alkalaemia, paresthesia, and tetany may occur. (05 Mar 2000) |
| chronic idiopathic jaundice | <syndrome> An inherited disorder (autosomal recessive) that is characterised by long-standing mild jaundice. This occurs secondary to an abnormality in the transport of bilirubin from the liver to the biliary system. This leads to an accumulation of bilirubin in the liver. Avoidance of alcohol and medications which can affect the liver is important. Inheritance: autosomal recessive. (27 Sep 1997) |
| chronic idiopathic xanthomatosis | Vague or indefinite term for inherited abnormalities of lipid metabolism leading to xanthoma formation (e.g., primary familial xanthomatosis). (05 Mar 2000) |
| chronic illness | An illness that has persisted for a long period of time. It is a continuing disease process. (12 Dec 1998) |
| chronic inflammation | An inflammation that may begin with a relatively rapid onset or in a slow, insidious, and even unnoticed manner, tends to persist for several weeks, months, or years and has a vague and indefinite termination; results when the injuring agent (or products resulting from its presence) persists in the lesion, and the host's tissues respond in a manner (or to a degree) that is not sufficient to overcome completely the continuing effects of the injuring agent. (05 Mar 2000) |
| chronic inflammatory demyelinating polyneuropathy | An uncommon, acquired, demyelinating sensorimotor polyneuropathy, clinically characterised by insidious onset, and slow evolution, (either steady progression or stepwise), and chronic course; symmetrical weakness is a predominant symptom, often involving proximal leg muscles, accompanied by paresthesias, but not pain; CSF examination shows elevated protein, while electrodiagnostic studies reveal evidence of a demyelinating process, primarily conduction slowing rather than block; sometimes responds to prednisone. (05 Mar 2000) |
| chronic inflammatory polyneuropathy | <neurology, pathology> A disorder that involves the slow progressive (or recurrent) inflammation of multiple nerves. Loss of movement and sensation are common findings. The exact cause is related to an abnormal immune response. The acute form of this illness is known as Guillain-Barre syndrome. Treatment often includes systemic corticosteroids or chemotherapeutic agents to suppress the immune system. Prognosis is variable. Origin: Gr. Pathos = disease (27 Sep 1997) |
| chronic interstitial hypertrophic neuropathy | dejerine-Sottas disease |
| chronic interstitial salpingitis | Salpingitis in which fibrosis or mononuclear cell infiltration involves all layers of the fallopian or eustachian tube. Synonym: pachysalpingitis. (05 Mar 2000) |