| basal cell layer | The deepest layer of the epidermis, composed of dividing stem cells and anchoring cells. Synonym: basal cell layer, columnar layer, germinative layer, palisade layer, stratum basale, stratum cylindricum, stratum germinativum. (05 Mar 2000) |
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| basal cell nevus | A hereditary disease noted in infancy or adolescence, characterised by lesions of the eyelids, nose, cheeks, neck, and axillae, appearing as uneroded flesh-coloured papules, some becoming pedunculated, and histologically indistinguishable from basal cell epithelioma; also noted are punctate keratotic lesions of the palms and soles; the lesions usually remain benign, but in some cases ulceration and invasion occur and are evidence of malignant change; autosomal dominant inheritance. (05 Mar 2000) |
| basal cell nevus syndrome | <syndrome> An inherited group of defects which involve abnormalities of the skin, eyes, nervous system, endocrine, glands and bones. The condition is characterised by an unusual facial appearance and a predisposition for skin cancer. (27 Sep 1997) |
| basal cell papilloma | A benign skin lesion resulting from excessive growth of the top layer of skin cells. It usually is found in persons over 30 years old and may be few or numerous. (12 Dec 1998) |
| basaloid cell | A cell, usually of the epidermis, resembling a basal cell. (05 Mar 2000) |
| basal squamous cell carcinoma | <tumour> A carcinoma of the skin which in structure and behaviour is considered transitional between basal cell and squamous cell carcinoma The term should not be used for the much more common keratotic variety of basal cell carcinoma, in which the tumour cells are of basal type but which contains small foci of abrupt keratinization. Synonym: basal squamous cell carcinoma. (05 Mar 2000) |
| basilar cell | <pathology> General term for relatively undifferentiated cells in an epithelial sheet that give rise to more specialised cells act as stem cells). In the stratified squamous epithelium of mammalian skin the basal cells of the epidermis (stratum basale) give rise by an unequal division to another basal cell and to cells that progress through the spinous, granular and horny layers, becoming progressively more keratinised, the outermost being shed as squames. In olfactory mucosa the basal cells give rise to olfactory and sustentacular cells. In the epithelium of epididymis their function is unclear, but they probably serve as stem cells. (13 Nov 1997) |
| basket cell | Cerebellar neurons with many small dendritic branches that enclose the cell bodies of adjacent Purkinje cells in a basket like array. (18 Nov 1997) |
| basophil cell of anterior lobe of hypophysis | beta cell of anterior lobe of hypophysis |
| B-cell | <haematology, immunology> A type of lymphocyte normally involved in the production of antibodies to combat infection. It is a precursor to a plasma cell. During infections, individual B-cell clones multiply and are transformed into plasma cells, which produce large amounts of antibodies against a particular antigen on a foreign microbe. This transformation occurs through interaction with the appropriate CD4 T-helper cells. (09 Oct 1997) |
| B-cell antigen receptors | In the primary immune response immunoglobulin D and monomeric immunoglobulin M are the B-cell antigen receptors. On memory B-cells, other immunoglobulin molecules can serve as antigen receptors. (05 Mar 2000) |
| B-cell differentiating factor | <cytokine> A soluble cytokine factor produced by activated T-lymphocytes that promotes antibody production by causing proliferation and differentiation of B-cells. Interleukin-4 induces the expression of class II major histocompatibility complex and fc receptors on B-cells. It also acts on T-lymphocytes, mast cell lines, and several other haematopoietic lineage cells including granulocyte, megakaryocyte, and erythroid precursors, as well as macrophages. Acronym: IL-4 (12 Dec 1998) |
| B-cell differentiation/growth factors | Various substances, usually obtained from the supernatant of T-cell cultures, such as interleukin 4, 5, and 6. These substances are necessary for B-cell growth, maturation, and differentiation into plasma cells or B memory cells. (05 Mar 2000) |
| B-cell leukaemia | A test which detects the presence of antigens on the surface of B lymphocytes. These antigens can indicate the presence of leukaemia. most often this is used to detect and differentiate chronic lymphocytic leukaemia from acute lymphocytic leukaemia. Origin: Gr. Haima = blood (27 Sep 1997) |
| B-cell stimulatory factor 2 | <cytokine> A cytokine that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts. A single chain 25 kD cytokine originally described as a pre B-cell growth factor, now known to have effects on a number of other cells including T-cells which are also stimulated to proliferate. An inducer of acute phase proteins and a colony-stimulating factor acting on mouse bone marrow. Acronym: IL-6 (12 Dec 1998) |