| prolactin-inhibiting factor | A substance of hypothalamic origin capable of inhibiting the synthesis and release of prolactin. Synonym: prolactin-inhibiting factor, prolactin-inhibiting hormone. Origin: prolactin + G. Stasis, standing still, + -in (05 Mar 2000) |
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| prolactin-releasing factor | A substance of hypothalamic origin that stimulates the release of prolactin. Synonym: prolactin-releasing factor, prolactin-releasing hormone. Origin: prolactin + L. Libero, to free, + -in (05 Mar 2000) |
| sarcoma growth factor | <growth factor> Polypeptide released by sarcoma cells that promotes the growth of cells by binding to a cell surface receptor, the sarcoma cell is therefore self sufficient and independent of normal growth control. See: growth factors. The name is no longer commonly used. (18 Nov 1997) |
| heparin binding growth factor | <growth factor> Acidic fibroblast growth factor (alpha FGF, HBGF 1) and basic FGF (beta FGF, HBGF 2) are the two founder members of a family of structurally related growth factors for mesodermal or neuroectodermal cells. Synonym: heparin binding growth factor. Acronym: FGF (18 Nov 1997) |
| properdin factor A | A component of the properdin system; a hydrazine-sensitive b1-globulin (mw about 180,000), now known to be C3 (third component of complement). (05 Mar 2000) |
| properdin factor b | <enzyme> A glycine-rich, heat-labile beta-glycoprotein found in blood. It is a proactivator of complement 3 in the alternate pathway of complement activation. Factor b is converted by factor d to c3 convertase. Registry number: EC 3.4.21.47 (12 Dec 1998) |
| properdin factor d | <enzyme> A serum protein which during the alternate pathway of complement activation converts the inactive properdin factor b to c3 convertase. Registry number: EC 3.4.21.46 (12 Dec 1998) |
| properdin factor E | A serum protein (mw 160,000) required for activation of C3 (third component of complement) by cobra venom factor. See: properdin system. (05 Mar 2000) |
| hepatocyte growth factor | <growth factor> Polypeptide mitogen originally shown to cause cell division in hepatocytes. In the liver, the main sources of hepatocyte growth factor are nonparenchymal cells. It is now clear that hepatocyte growth factor is a mitogen for a number of cell types and it is found in many cells outside the liver, including platelets. Hepatocyte growth factor is synthesised as a single chain precursor that is proteolytically cleaved to give a heavy chain (70 kD) and a light chain (30 kD) linked by a single disulphide bond. It contains multiple copies of the kringle domain. However, both the single chain precursor and the two chain forms of hepatocyte growth factor are biologically active and hepatocyte growth factor is generally isolated as a mixture of the two forms. Hepatocyte growth factor also alters cell motility and is now known to be identical to scatter factor. Acronym: HGF (18 Nov 1997) |
| scatter factor | A motility factor (motogen) isolated from conditioned medium in which human fibroblasts have been grown. It causes colonies of epithelial and endothelial cells, in culture, to separate into single cells that move apart i.e. They scatter. It has been shown to be identical to human hepatocyte growth factor, but it is not mitogenic for all cell types. (18 Nov 1997) |
| proteinase inhibitor inducing factor | See: PIIF. (18 Nov 1997) |
| protein factor | The factor (6.25) by which the nitrogen content of a protein is multiplied to give the amount of protein. (05 Mar 2000) |
| pro-transforming growth factor-alpha processing protease | <enzyme> Converts membrane-bound protgf-alpha to soluble tgf-alpha; mw 84 kD Registry number: EC 3.4.21.- Synonym: protgf-alpha converting enzyme, protgfalpha processing protease (26 Jun 1999) |
| schwannoma derived growth factor | <growth factor> A growth factor containing an EGF like domain, mitogenic for astrocytes, Schwann cells and fibroblasts. (18 Nov 1997) |
| HG factor | A polypeptide hormone (3485 D) secreted by the cells of the Islets of Langerhans in response to a fall in blood sugar levels. Induces hyperglycaemia. A family of structurally related peptides includes glucagon like peptides 1 & 2 (encoded by the same gene), gastric inhibitory polypeptide, secretin, vasoactive intestinal peptide, growth hormone releasing factor, pituitary adenylate cyclase activating polypeptide, exendins. (18 Nov 1997) |