| deoxyribonucleases, type I site-specific | <enzyme> Enzyme systems containing three different subunits and requiring ATP, s-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent atpases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognise specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.3 (12 Dec 1998) |
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| IgA-specific serine endopeptidase | <enzyme> Extracellular microbial enzymes whose only substrate is human IgA of the iga1 subclass; cleave the immunoglobulin at a specific internal prolyl-threonyl peptide bond in the heavy chain to yield intact faba and fca fragments; consider also EC 3.4.24.13 Registry number: EC 3.4.21.72 Synonym: immunoglobulin a(1) protease, iga1 protease, immunoglobulin a1 protease, IgA protease (26 Jun 1999) |
| organ-specific | Denoting or pertaining to a serum produced by the injection of the cells of a certain organ or tissue that, when injected into another animal, destroys the cells of the corresponding organ. (05 Mar 2000) |
| organ-specific antigen | A heterogenetic antigen with organ specificity; e.g., in addition to species-specific antigen, kidney of one species contains antigen that is identical to that in kidney of other species. Synonym: tissue-specific antigen. (05 Mar 2000) |
| tail-specific protease | <enzyme> Selectively degrades proteins with nonpolar c termini Registry number: EC 3.4.99.- Synonym: tsp protease, prc protein, prc gene product (26 Jun 1999) |
| tissue-specific antigen | A heterogenetic antigen with organ specificity; e.g., in addition to species-specific antigen, kidney of one species contains antigen that is identical to that in kidney of other species. Synonym: tissue-specific antigen. (05 Mar 2000) |
| tumour specific antigen | <immunology, oncology> Antigen on tumour cells detected by cell-mediated immunity. For virus transformed cells TSTA (unlike T antigen) is found to differ for different individual tumours induced by the same virus. May consist of fragments of T antigens exposed at the cell surface. (18 Nov 1997) |
| tumour-specific transplantation antigens | Surface antigen's of DNA tumour virus-transformed cells, which elicit an immune rejection of the virus-free cells when transplanted into an animal that has been immunised against the specific cell-transforming virus. (05 Mar 2000) |
| uridine-specific acid nuclease | <enzyme> Chicken liver enzyme hydrolyzes poly(u) and e. Coli RNA Registry number: EC 3.1.- (26 Jun 1999) |
| fluoroacetate-specific dehalogenase | <enzyme> Acts on fluoroacetamide at 0.1 the rate for fluoroacetate Registry number: EC 3.8.1.- Synonym: fluoroacetate-specific defluorinase, fac dehalogenase (26 Jun 1999) |
| lymphocyte specific protein tyrosine kinase p56(lck) | <enzyme> This enzyme is a lymphoid specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the il-2 receptor, and is thought to be involved in the earliest steps of tcr-mediated T-cell activation. Registry number: EC 2.7.11.- (12 Dec 1998) |
| abducens nerve | <anatomy, nerve> The 6th cranial nerve. The abducens nerve originates in the abducens nucleus of the pons and sends motor fibres to the lateral rectus muscles of the eye. Damage to the nerve or its nucleus disrupts horizontal eye movement control. (12 Dec 1998) |
| abducent nerve | <anatomy> The abducent nerve enervates a muscle which moves the eyeball. Lesions of the sixth cranial nerve result in deviation of the eyeball outward and double vision. Synonym: cranial nerve VI. (27 Sep 1997) |
| accessory nerve | <anatomy, nerve> The accessory nerve enervates the sternocleidomastoid muscles and the trapezius muscles. Lesions of the eleventh result in drooping of the shoulder and inability to rotate the head away from the affected side. Synonym: cranial nerve XI. (27 Sep 1997) |
| accessory nerve lymph nodes | The nodes of the lateral deep cervical group that are located along the accessory nerve; their efferent vessels pass to the supraclavicular lymph nodes. Synonym: companion lymph nodes of accessory nerve, nodi lymphatici comitantes nervi accessorii. (05 Mar 2000) |