| caroli's disease | Congenital cystic dilatation of the intrahepatic bile ducts. It consists of 2 types: simple, with bile duct dilatation or ectasia alone, and complex, with associated extensive hepatic fibrosis and portal hypertension. Benign renal tubular ectasia is associated with both types. (12 Dec 1998) |
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| rabbit haemorrhagic disease | A highly infectious disease of rabbits, caused by a calicivirus and characterised by haemorrhagic lesions, particularly affecting the lungs and liver; since it was first identified in China in 1984, it has been reported from Korea, it has spread through Europe, and it has reached North Africa and Mexico. (05 Mar 2000) |
| machado-joseph disease | A progressive degenerative disease of the central nervous system occurring in portuguese-azorean families, having a variety of forms and inherited as an autosomal dominant trait. There are four major types: type I: with pyramidal and extrapyramidal deficits; type II: with cerebellar, pyramidal and extrapyramidal deficits; type III: with cerebellar deficits and distal sensorimotor neuropathy; type IV: with parkinsonism and distal sensory neuropathy. It was originally reported in two portuguese-azorean families in massachusettes (machado), then in another portuguese family (thomas), and later in a third family in california (joseph, who settled there in 1845). It has been reported also in japanese families. (12 Dec 1998) |
| Paas' disease | A familial skeletal deformation marked by coxa valga, double patella, shortening of the middle and terminal phalanges of fingers and toes, deformities of the elbows, scoliosis, and spondylitis deformans of the lumbar vertebrae; all of these manifestations may be unilateral or bilateral. (05 Mar 2000) |
| Gairdner's disease | <disease> Attacks of cardiac distress accompanied by apprehension. Synonym: angina pectoris sine dolore, angor pectoris. (05 Mar 2000) |
| Pacheco's disease | A highly contagious, acute disease of psittacine birds caused by a herpesvirus and characterised by bright yellow urates with scant faeces, icterus, and terminal anorexia. (05 Mar 2000) |
| Pacheco's parrot disease virus | Probably a virus of the family Herpesviridae, possibly related to the virus of infectious laryngotracheitis. Synonym: parrot virus. (05 Mar 2000) |
| vagabond's disease | Excoriations and melanoderma caused by scratching the bites of the body louse, Pediculus corporis. Synonym: Greenhow's disease, vagabond's disease, vagrant's disease. Racial melanoderma, the normally dark skin of blacks and certain other races. Senile melanoderma, cutaneous pigmentation occurring in the aged. Synonym: melasma universale. (05 Mar 2000) |
| gallbladder disease | <gastroenterology, surgery> An inflammatory condition of the gallbladder that usually results from the presence of gallstones and repeated bouts of cholecystitis. (27 Sep 1997) |
| paget disease | <radiology> Disease of unknown aetiology involving destruction and reparation, age greater than 40y; M:F 2:1, skull, osteoporosis circumscripta (outer table destroyed only), cotton wool appearance, increased hat size!, spine, monostotic vertebral involvment usually, pelvis, affected in 2/3 cases, consists of cortical thickening, enlargement of pubis/ischium, coarse trabecular pattern, extremities, blade of grass appearance, elevation of alk phos (up to 20X), normal calcium, normal phosphorus, complications: path fractures in 8% cases (usually femur = shepard's crook), malignant degeneration (usually osteosarcoma-50%, fibrosarcoma-25%) (12 Dec 1998) |
| paget disease of breast | <radiology> Form of ductal carcinoma, associated with eczematous changes of the nipple (12 Dec 1998) |
| Paget's disease | <disease, rheumatology> This is a disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue. Many patients are asymptomatic and diagnosed by routine X-rays. (13 Nov 1997) |
| paget's disease, extramammary | A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (devita jr et al., cancer: principles & practice of oncology, 3d ed, p1478) (12 Dec 1998) |
| paget's disease, mammary | An intraductal carcinoma of the breast extending to involve the nipple and areola, characterised clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (paget's cells). (12 Dec 1998) |
| Paget's disease of the nipple | <oncology, tumour> A cancer of the nipple. (16 Dec 1997) |