| HLA-dr3 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. It is in linkage disequilibrium with HLA-a1 and HLA-b8. The HLA-dr3 antigen is strongly associated with coeliac disease, grave's disease, dermatitis herpetiformis, early-age onset myasthenia gravis, systemic lupus erythematosus, juvenile diabetes, and opportunistic infections in aids. (12 Dec 1998) |
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| HLA-dr4 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. It is strongly associated with rheumatoid arthritis and juvenile diabetes. (12 Dec 1998) |
| HLA-dr5 antigen | <immunology> Human immune-response, d-related antigen encoded by the d-locus on chromosome 6 and found on lymphoid cells. It is associated with kaposi sarcoma in aids and juvenile rheumatoid arthritis. (12 Dec 1998) |
| HLA-dr6 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. (12 Dec 1998) |
| HLA-dr7 antigen | <immunology> Human immune-response, d-related antigen encoded by the d locus on chromosome 6 and found on lymphoid cells. It is strongly associated with coeliac disease and psoriasis vulgaris. (12 Dec 1998) |
| homologous antigen | <immunology> A homologous antigen is one which will attract and react with a specific antibody. (09 Oct 1997) |
| self antigen | <immunology> The antigens of an organisms own cells and cell products are self antigens to the immune system of that organisn. Clones of immune cells reactive with self antigens are normally eliminated. (18 Nov 1997) |
| senescent cell antigen | <immunology> An antigen (62 kD) that appears on the surface of senescent erythrocytes and is immunologically cross reactive with isolated Band III protein. Seems to be recognised by an autoantibody and the immunoglobulin coated erythrocyte is then removed from circulation by cells such as Kuppfer cells of the liver that have Fc receptors. Intracellular cleavage of intact band III by a calcium activated protease, calpain, may reveal the antigen in situ. (18 Nov 1997) |
| sensitised antigen | The complex formed when antigen combines with specific antibody; so called because the antigen, by the mediation of antibody, is rendered sensitive to the action of complement. (05 Mar 2000) |
| human leukocyte antigen | <immunology> A genetic fingerprint on white blood cells and platelets, composed of proteins that play a critical role in activating the bodys immune system to respond to foreign organisms. Acronym: HLA (16 Dec 1997) |
| human lymphocyte antigen | A system designation for the gene products of at least four linked loci (A, B, C, and D) and a member of subloci on the sixth human chromosome which have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and certain disease associations; more than 50 alleles are recognised, most of which are at loci HLA-A and HLA-B; autosomal dominant inheritance. (05 Mar 2000) |
| serum factor VIII antigen | A test used to measure the activity of a blood clotting factor VIII (Von Willebrand factor). This test is usually used to monitor treatment of haemophilia. Abnormally low factor VIII assays may be seen in the following conditions: congenital deficiency of factor VIII (haemophilia), DIC and secondary fibrinolysis. This test may also be performed in the evaluation of Von Willebrand's disease. (27 Sep 1997) |
| h-y antigen | A sex-specific cell surface antigen produced by the sex-determining gene of the y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis. (12 Dec 1998) |
| shock antigen | An antigen capable of producing anaphylactic shock in an animal that has been sensitised to it. (05 Mar 2000) |
| soluble antigen | Viral antigen that remains in solution after the particles of virus have been removed by means of centrifugation; in the case of the influenza viruses, it is the internal helical structure, free of the external envelope. Synonym: S antigen. (05 Mar 2000) |