| acute intermittent porphyria | <gastroenterology, haematology> A group of rare inherited metabolic disorders that result from a disturbance in porphyrin metabolism, causing increased formation and excretion of porphyrin or its precursors. It is caused by hepatic overproduction of d-aminolevulinic acid, which has greatly increased urinary excretion and of porphobilinogen, and some increase of uroporphyrin, due to a deficiency of porphobilinogen deaminase. Clinical features: intermittent acute attacks of hypertension, abdominal colic, psychosis, and polyneuropathy, but with no photosensitivity. It is exacerbated by the ingestion of certain drugs such as; barbiturates). Inheritance: autosomal dominant. (20 Sep 2002) |
|---|---|
| acute interstitial nephritis | <nephrology> A relatively uncommon condition which is characterised by inflammation of the renal tubules, glomeruli and surrounding tissue. Interstitial nephritis is usually be temporary and often associated with the use of a particular medication. Chronic and progressive forms do exist. Drugs that have been associated with interstitial nephritis include penicillins, ampicillin, sulpha drugs, non-steroidal anti-inflammatory agents, furosemide and thiazide diuretics. May result in mild kidney dysfunction or acute renal failure. Treatment may be with corticosteroids. Incidence: 1 in 25,000. (29 Dec 1997) |
| acute interstitial pneumonia | A severe and usually fatal form of pneumonia occurring primarily in infants usually considered a form of hypersensitivity pneumonitis. (05 Mar 2000) |
| acute interstitial pneumonitis | Usually considered a form of hypersensitivity pneumonitis. (05 Mar 2000) |
| acute kidney failure | <nephrology> A sudden decline in renal function may be triggered by a number of acute disease processes. Examples include sepsis (infection), shock, trauma, kidney stones, kidney infection, drug toxicity (aspirin or lithium), poisons or toxins (drug abuse) or after injection with an iodinated contrast dye (adverse effect). Chronic renal failure represents a slow decline in kidney function over time. Chronic renal failure may be caused by a number of disorders which include long-standing hypertension, diabetes, congestive heart failure, lupus or sickle cell anaemia. Both forms of renal failure result in a life-threatening metabolic derangement. (27 Sep 1997) |
| acute kidney transplant rejection | <radiology> Findings on ultrasound: globular enlargment of the kidney, swelling and hypoechogenicity of the medullary pyramids, indistinct cortico-medullary junction, foci in the renal cortex (12 Dec 1998) |
| acute leukaemia | <haematology> A rapidly progressive cancer of the blood of sudden onset and characterised by the uncontrolled proliferation of immature blood cells which take over the bone marrow and spill into the blood stream. If left untreated is fatal within a few weeks or months. See: acute lymphoblastic leukaemia, acute myeloid leukaemia. Origin: Gr. Haima = blood (11 Nov 1997) |
| acute lobar nephrosis | A severe but localised bacterial infection of the renal parenchyma that may produce a mass effect simulating a renal abscess. (05 Mar 2000) |
| acute lower GI haemorrhage | <gastroenterology> Typical presentation: Sudden onset of brisk rectal bleeding without blood in gastric aspirate Diagnostic considerations: diverticulosis, angiodysplasia, ischemic colitis, inflammatory bowel disease (rarely), polyps are usually present, carcinoma causing a chronic bleed, haemorrhoids. (12 Dec 1998) |
| acute lymphoblastic leukaemia | <haematology> A rapidly progressing cancer of the blood affecting the type of white blood cell known as lymphocytes. Approximately 650 new cases are diagnosed every year in the UK and it is the most common form of childhood leukaemia. Acronym: ALL Origin: Gr. Haima = blood (11 Nov 1997) |
| acute lymphocytic leukaemia | <radiology> 95% of cases of leukaemia in children, bone changes in 50-70% of kids (vs. 10% in adults); seen as early as 1 month after onset of symptoms, wrists and knees most commonly affected, bony defects: metaphyseal radiolucent bands! (similar findings in scurvy, JRA, syphilis), osteolytic lesions, periosteal reaction, osteosclerosis (12 Dec 1998) |
| acute malaria | A form of malaria that may be intermittent or remittent, consisting of a chill accompanied and followed by fever with its attendant general symptoms, and terminating in a sweating stage; the paroxysms, caused by release of merozoites from infected cells, recur every 48 hours in tertian (vivax or ovale) malaria, every 72 hours in quartan (malariae) malaria, and at indefinite but frequent intervals, usually about 48 hours, in malignant tertian (falciparum) malaria. (05 Mar 2000) |
| acute mania | An excited mental state seen in a bipolar (manic-depressive) disorder characterised by hyperactivity, talkativeness, flight of ideas, pressured speech, grandiosity, and, occasionally, grandiose delusions. See: mania, manic-depressive. Synonym: acute mania. (05 Mar 2000) |
| acute miliary tuberculosis | A rapidly fatal disease due to the general dissemination of tubercle bacilli in the blood, resulting in the formation of miliary tubercles in various organs and tissues, and producing symptoms of profound toxaemia. Synonym: acute miliary tuberculosis, disseminated tuberculosis. (05 Mar 2000) |
| acute monocytic leukaemia | <haematology> The most common translocation in this disorder of poorly differentiated monocytic cells involves chromosome region 11q in a large percentage of cases. The translocation involves a cellular oncogene, c-ets which is mapped to the 11q23-24 region. The most common translocations reported are t(6;11), t(9;11), t(11;17) and t(11;19), of which t(9;11) (p21-22;q23) is by far the most frequently detected and implicated in acute myeloid leukaemia. The cells express CD14 surface antigen, which is diagnostic of monocytic cells. Acronym: AML Classification: FAB M5 (07 Apr 1998) |